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Related Experiment Video

Updated: Apr 17, 2026

Use of Synaptic Zinc Histochemistry to Reveal Different Regions and Laminae in the Developing and Adult Brain
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Zinc: indications in brain disorders.

Atish Prakash1, Kanchan Bharti, Abu Bakar A Majeed

  • 1Brain Degeneration and Therapeutics Group, Brain and Neuroscience Communities of Research, Universiti Teknologi MARA (UiTM), Shah Alam, 40450, Malaysia; Department of Pharmacology, ISF college of Pharmacy, Ghal kalan, Moga, 142-001, India; Brain Research Laboratory, Faculty of Pharmacy, Campus Puncak Alam, Universiti Teknologi MARA (UiTM), Bandar Puncak Alam, 42300, Malaysia.

Fundamental & Clinical Pharmacology
|February 10, 2015
PubMed
Summary

Zinc is vital for brain function, impacting neuronal signaling and synaptic plasticity. Dysregulation of zinc homeostasis is linked to numerous neurological disorders, highlighting its importance in brain health.

Keywords:
Alzheimer's diseasedepressionepilepsyneurotoxicityprion diseasestrokezinc

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Area of Science:

  • Neuroscience
  • Biochemistry
  • Cell Biology

Background:

  • Zinc is an essential metal in the human body, critical for neuronal signaling and synaptic function.
  • It acts as a modulator of synaptic activity and neuronal plasticity throughout development and adulthood.
  • Zinc homeostasis is maintained by various importers and transporters, with ZnT-3 being a key player in the brain.

Purpose of the Study:

  • To explore the critical role of zinc in the brain.
  • To understand the mechanisms governing brain zinc homeostasis.
  • To investigate the link between altered zinc status and neurological disorders.

Main Methods:

  • Review of existing literature on zinc's role in the central nervous system.
  • Analysis of the function of zinc transporters, particularly ZnT-3.
  • Examination of the association between zinc dyshomeostasis and various neurological conditions.

Main Results:

  • Zinc is crucial for presynaptic neuronal signaling and synaptic function.
  • Altered brain zinc levels are implicated in neurodevelopmental issues and neurodegenerative diseases like Alzheimer's, Parkinson's, and Huntington's.
  • Zinc's role extends to mood disorders and neuronal damage from injury, stroke, and seizures.

Conclusions:

  • Understanding brain zinc homeostasis mechanisms is essential for developing therapeutic strategies.
  • Targeting zinc regulation may offer novel approaches for treating a spectrum of neurological disorders.
  • Further research into zinc's precise roles can unlock new avenues for neuroprotection and disease management.