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LDL cholesterol and apolipoprotein B are associated with ascending aorta dilatation in bicuspid aortic valve patients

J M Alegret1, L Masana2, N Martinez-Micaelo3

  • 1From the Grup de Recerca Cardiovascular, Hospital Universitari de Sant Joan, IISPV, Universitat Rovira i Virgili, Reus, Spain and josepmaria.alegret@urv.cat.

QJM : Monthly Journal of the Association of Physicians
|February 10, 2015
PubMed

Insights

Cholesterol levels, including LDL cholesterol and apolipoprotein B, correlate with ascending aorta dilation in bicuspid aortic valve patients. These lipid markers may predict aortic root and ascending aorta diameter changes.

Area of Science:

  • Cardiovascular Medicine
  • Genetics and Genomics
  • Biochemistry

Background:

  • Ascending aorta dilation (AAD) in bicuspid aortic valve (BAV) patients is not fully understood.
  • The impact of cholesterol metabolism on AAD remains uninvestigated.

Purpose of the Study:

  • To investigate the association between lipid parameters and ascending aorta diameter/dilatation in BAV patients.
  • To identify potential lipid biomarkers for AAD in BAV.

Main Methods:

  • Retrospective analysis of 91 consecutive BAV patients.
  • Correlation analysis between lipid profiles (total cholesterol, LDL, ApoB) and aortic dimensions.
  • Identification of independent predictors for aortic diameter.

Main Results:

  • Positive linear correlation observed between total cholesterol, LDL cholesterol, apolipoprotein B (ApoB) and ascending aorta diameter.
  • Patients with AAD exhibited higher LDL cholesterol and ApoB levels.
  • ApoB was an independent predictor of ascending aorta diameter, while both LDL and ApoB predicted aortic root diameter.

Conclusions:

  • Cholesterol metabolism is significantly associated with ascending aorta diameter and dilation in BAV patients.
  • ApoB emerges as a key independent predictor for aortic dimensions in this cohort.
  • Further research is warranted to elucidate the underlying pathobiology.
Abstract

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