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Allergogenic profile in patients with different subtypes of chronic rhinosinusitis with nasal polyps
Ming Xu1, Xiaolei Ye, Feng Zhao
1Department of Otorhinolaryngology, the Affiliated Hospital of the Medical School of Ningbo University, Ningbo, China.
Aims:
The aim of this study was to analyze the relationship between allergy and different subtypes of chronic rhinosinusitis with nasal polyps (CRSwNP).
Methods:
A total of 83 patients with CRSwNP and 20 patients with nasal septum deviation (NSD) as controls were enrolled in our study. Nasal tissue was obtained from all subjects during surgery. Hematoxylin and eosin staining was performed and the CRSwNP cases were classified into eosinophilic nasal polyps (ENP) and noneosinophilic nasal polyps (nENP) cases according to the percent of eosinophils. The Allergy Screen test was used to detect total and specific immunoglobulin E (IgE) against 5 kinds of common inhalant allergens.
Results:
There were 28 (33.73%) patients with ENP and 55 with nENP. Total IgE levels were significantly increased in ENP compared with nENP patients. The IgE level was significantly correlated with the eosinophil count. According to the 5 kinds of common inhalant allergens, only ENP patients exhibited higher sensitivity to dust mites.
Conclusion:
Patients with ENP showed significantly higher IgE levels when compared with patients with nENP based on allergy.
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