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Overexpression of phosphorylated 4E-binding protein 1 and its clinicopathological significances in gastric cancer

Hyoun Wook Lee1, Moon-Il Park1, Mee-Seon Kim1

  • 1Department of Pathology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, South Korea.

Pathology, Research and Practice
|February 10, 2015
PubMed

Insights

Phosphorylated 4E-binding protein 1 (p-4E-BP1) is more common in early gastric cancer. High p-4E-BP1 expression correlates with better survival but is not an independent prognostic factor.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Transforming signals regulate eukaryotic translation initiation factor 4E (eIF4E)-binding protein (4E-BP1) through phosphorylation.
  • Phosphorylation of 4E-BP1 releases eIF4E, relieving translational repression and promoting oncogenic protein synthesis.

Purpose of the Study:

  • To assess phosphorylated 4E-BP1 (p-4E-BP1) expression in gastric cancer.
  • To correlate p-4E-BP1 expression with clinicopathological parameters and patient survival.

Main Methods:

  • Generated tissue microarray blocks from 179 gastric carcinomas.
  • Performed immunohistochemical staining for p-4E-BP1.

Main Results:

  • p-4E-BP1 expression was higher in intestinal-type tumors, smaller tumors (<5cm), lower pathological T, N, and TNM stages, and in cases without distant metastasis.
  • High p-4E-BP1 expression correlated with prolonged overall and disease-free survival.
  • p-4E-BP1 was not an independent prognostic factor in multivariate analysis.

Conclusions:

  • p-4E-BP1 is more highly expressed in early-stage gastric cancers.
  • p-4E-BP1 has limited potential as an independent prognostic biomarker in gastric cancer.
  • Further studies are needed to clarify the prognostic significance and mechanism of p-4E-BP1 in gastric cancer.
Keywords:
Gastric cancerImmunohistochemistryPrognosisp-4E-BP1

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