Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

14.7K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
14.7K
Drug Toxicity: Risk factors01:24

Drug Toxicity: Risk factors

214
Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...
214
Factors Affecting Protein-Drug Binding: Patient-Related Factors01:29

Factors Affecting Protein-Drug Binding: Patient-Related Factors

447
Protein-drug binding, a pivotal aspect of pharmacokinetics, is subject to considerable variability influenced by an array of patient-related factors. The intricate interplay of age, individual differences, and pathological conditions significantly impact the binding dynamics and subsequent pharmacological effects.
Age stands as a key determinant in protein-drug binding. Neonates, characterized by low albumin content, experience heightened concentrations of unbound drugs such as phenytoin and...
447
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

181
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
181
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

88.4K
Overview
88.4K
Autoimmune Disorders01:29

Autoimmune Disorders

2.3K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
2.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A perspective on ABO incompatible transplantation.

Human immunology·2026
Same author

Forced treadmill exercise in the male rat: effect on food intake and c-Fos expression.

Physiology & behavior·2025
Same author

Less than full time training in plastic surgery: A qualitative survey-based study and practical suggestions for improvement.

Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2022
Same author

Clinical and pathological feature of bone marrow granulomas: A modern Australian series.

International journal of laboratory hematology·2017
Same author

Can serological methods help distinguish between prophylactic and alloimmune anti-D?

Transfusion medicine (Oxford, England)·2017
Same author

Selecting haematological malignancy patients for intravenous immunoglobulin.

Internal medicine journal·2016

Related Experiment Video

Updated: Apr 17, 2026

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade
11:55

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade

Published on: March 14, 2011

15.1K

Risk factors for alloimmunisation in the general patient population.

S Eccles1, P Crispin2, T Vanniasinkam3

  • 1ACT Pathology, The Canberra Hospital, Canberra, Australia; Charles Sturt University, Wagga Wagga, Australia.

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis
|February 10, 2015
PubMed
Summary
This summary is machine-generated.

Identifying patients at risk of alloimmunisation is crucial for hospitals. This study found that sepsis, hematological malignancy, gastrointestinal bleeds, and renal failure are common diagnoses in alloimmunised patients.

Keywords:
AlloimmunisationRed cell antibodyTransfusion

More Related Videos

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
08:07

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Published on: September 6, 2017

10.7K
Generation of Human Alloantigen-specific T Cells from Peripheral Blood
09:47

Generation of Human Alloantigen-specific T Cells from Peripheral Blood

Published on: November 21, 2014

13.7K

Related Experiment Videos

Last Updated: Apr 17, 2026

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade
11:55

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade

Published on: March 14, 2011

15.1K
Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
08:07

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Published on: September 6, 2017

10.7K
Generation of Human Alloantigen-specific T Cells from Peripheral Blood
09:47

Generation of Human Alloantigen-specific T Cells from Peripheral Blood

Published on: November 21, 2014

13.7K

Area of Science:

  • Transfusion Medicine
  • Immunology
  • Patient Safety

Background:

  • Hospitals serving regional populations face challenges with transferred patients who have incomplete medical histories.
  • A significant risk factor for complications is alloimmunisation, which occurs when a patient develops antibodies against foreign antigens.
  • Early identification of patients at risk of alloimmunisation is essential for effective treatment planning and preventing adverse events.

Purpose of the Study:

  • To identify demographic and diagnostic factors associated with alloimmunisation in a patient population.
  • To compare the characteristics of alloimmunised patients with a control group to find distinguishing features.
  • To aid in the development of targeted strategies for risk assessment and management in transfusion medicine.

Main Methods:

  • A retrospective study design was employed.
  • Alloimmunised patients were identified and their data compared with a control patient group.
  • Demographic information and primary diagnoses were analyzed for significant differences between the groups.

Main Results:

  • The alloimmunised patient group showed a higher prevalence of diagnoses including Sepsis, Haematological Malignancy, Gastrointestinal (GIT) Bleeds, and Renal Failure.
  • RhD negative status and female sex were over-represented in the alloimmunised cohort.
  • The alloimmunised patient group was, on average, significantly older than the control group.

Conclusions:

  • Specific diagnoses such as Sepsis, Haematological Malignancy, GIT Bleeds, and Renal Failure are associated with an increased risk of alloimmunisation.
  • RhD negative, female, and older patients represent key demographic groups at higher risk.
  • These findings can inform clinical practice for better risk stratification and preventative strategies in transfusion-dependent patients.