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MDR1 C3435T polymorphism and childhood acute lymphoblastic leukemia susceptibility: an updated meta-analysis
Qingfang Yue1, Bei Xiong2, Lei Chen1
1Department of Hematology, The Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, PR China.
Background:
Acute lymphoblastic leukemia (ALL) is the most common malignancy in children, though the etiology of the leukemia is poorly understood, both genetic and environmental factors appear to be involved. Previous studies investigating the association between MDR1 C3435T polymorphisms and risk of children with ALL reported controversial results.
Methods:
We performed a comprehensive meta-analysis to clarify the effect of MDR1 C3435T polymorphisms on risk of childhood ALL. The strength of the association was measured by odds ratio (OR) with 95% confidence interval (CI).
Results:
Nine studies were finally included, involving a total of 1462 cases and 1522 controls. There was no association between MDR1 C3435T polymorphism and children ALL risk in all of four models in overall populations (CT vs. CC: OR=0.86, 95% CI=0.65-1.15, P=0.310; TT vs. CC: OR=1.50, 95% CI=0.96-2.35, P=0.076; TT/CT vs. CC: OR=1.12, 95% CI=0.95-1.33, P=0.166; TT vs.
Cc/Ct:
OR=1.58, 95% CI=0.97-2.56, P=0.067). Subgroup analysis by race suggested that this association existed in Asians under the under the homozygote model and recessive model (TT vs. CC: OR=2.45, 95% CI=1.24-4.86, P=0.010; TT vs.
Ct/Cc:
OR=2.65, 95% CI=1.22-5.75, P=0.014).
Conclusions:
This meta-analysis suggests there was no association between MDR1 C3435T polymorphism and children ALL risk in overall populations, but significant association with an increased risk in Asians.
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