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Postinfectious functional gastrointestinal disorders in children: a multicenter prospective study

Licia Pensabene1, Valentina Talarico1, Daniela Concolino1

  • 1Department of Pediatrics, University Magna Graecia, Catanzaro, Italy.

The Journal of Pediatrics
|February 10, 2015
PubMed

Insights

Children experiencing acute diarrhea are at higher risk for developing functional gastrointestinal disorders (FGIDs). This study confirms postinfectious FGIDs are a significant entity, particularly those involving abdominal pain, persisting for months after infection.

Area of Science:

  • Pediatric Gastroenterology
  • Infectious Diseases
  • Functional Gastrointestinal Disorders

Background:

  • Functional gastrointestinal disorders (FGIDs) are common in children.
  • The link between acute infectious diarrhea and the subsequent development of FGIDs requires further investigation.

Purpose of the Study:

  • To prospectively investigate the incidence of postinfectious functional gastrointestinal disorders (FGIDs) in children following acute diarrhea of varying infectious causes.
  • To diagnose FGIDs using Rome III criteria.

Main Methods:

  • A prospective, multicenter cohort study involving children aged 4-17 with acute diarrhea and confirmed enteric infection.
  • Patients were matched with control subjects and evaluated for FGIDs using a validated questionnaire at enrollment and at 3 and 6 months post-infection.

Main Results:

  • FGIDs were significantly more prevalent in children with a history of acute diarrhea compared to controls at 1, 3, and 6 months post-infection (RR 1.9-2.2).
  • Abdominal pain-related FGIDs were notably more frequent in the exposed group after 6 months (RR 1.7).
  • No correlation was found between specific infection etiologies, age, or sex and FGID development.

Conclusions:

  • Postinfectious FGIDs represent a distinct clinical entity in children.
  • Acute diarrhea significantly increases the risk of developing FGIDs, especially those characterized by abdominal pain, in the months following infection.
Abstract

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