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Updated: Apr 17, 2026

Utero-tubal Embryo Transfer and Vasectomy in the Mouse Model
Published on: February 28, 2014
[Treatment of tubal ectopic pregnancy by methotrexate]
M Lesavre1, S Curinier2, P Capmas1
1Service de gynécologie-obstétrique, CHU Bicêtre, 78, avenue du général-Leclerc, 94276 Le Kremlin-Bicêtre, France.
Objectives:
To make a literature analyse about methotrexate as a treatment of tubal ectopic pregnancy.
Materials And Methods:
We made a PubMed research and found articles, randomized control studies, systematic revues and meta-analyses of the Cochrane Database about ectopic pregnancies treated by methotrexate. We made a summary of these articles.
Results:
Methotrexate can be used as a treatment of tubal ectopic pregnancy with hCG<5000 UI/L and expectative is an option if hCG level is lower than 1500 UI/L. Medical treatment by methotrexate seems to be less effective than surgical salpingotomy but the rate of recurrence and the rate of intra-uterine pregnancy are similar regardless of the treatment chosen. Fertility seems to be the same after treatment by methotrexate. Economically, methotrexate is less expensive than the surgical management (laparoscopy).
Conclusion:
Methotrexate can be used as a treatment of tubal ectopic pregnancies if every criterions of safety are gathered.
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