[Importance of annexin V in kidney diseases]

Area of Science:

• Nephrology
• Cell Biology
• Biochemistry

Background:

• Annexin V (AnV) is a calcium-binding protein implicated in apoptosis.
• AnV serves as an early apoptosis marker, vital for detecting cellular changes.
• Renal processes and various kidney conditions are linked to AnV levels.

Purpose of the Study:

• To explore the role of Annexin V in various renal conditions.
• To evaluate AnV as a marker for apoptosis in kidney diseases.
• To investigate AnV's significance in acute and chronic renal pathologies.

Main Methods:

• Utilized Annexin V detection to identify early apoptosis in tubular cells.
• Assessed AnV levels in patients with acute pyelonephritis, diabetic nephropathy, and chronic renal conditions.
• Examined the influence of bacterial hemolysins and reperfusion injury on tubular cell apoptosis.
• Evaluated AnV as a biomarker for atherosclerosis and immunodeficiency in chronic kidney disease patients.
• Investigated the prognostic value of AnV in pediatric nephrotic syndrome.

Main Results:

• Escherichia coli hemolysins were shown to induce tubular cell death, with intensity dependent on toxin levels and exposure time.
• A synthetic AnV homodimer demonstrated protective effects against tubular cell injury during renal reperfusion.
• AnV measurement showed potential as a biomarker for atherosclerosis and immunodeficiency in chronic renal disease.
• AnV levels correlated with apoptosis intensification in renal tubular cells affected by metabolic disorders in diabetic nephropathy.
• The prognostic value of AnV and T-cell apoptosis was assessed in children with nephrotic syndrome.

Conclusions:

• Annexin V is a significant indicator in various renal conditions, including infections, metabolic disorders, and injury.
• AnV measurement offers potential for early diagnosis, prognosis, and therapeutic evaluation in nephrology.
• Further research into AnV's role, particularly in pediatric renal diseases, is warranted.