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CASP3 genetic variants and susceptibility to atrial fibrillation in Chinese Han population

Zhurong Luo1, Chenghui Yan2, Ping Yu3

  • 1Department of Cardiology, Fuzhou General Hospital, Fujian Medical University, Fuzhou 350025, China.

International Journal of Cardiology
|February 10, 2015
PubMed

Insights

Genetic variants in the CASP3 gene, specifically the rs4647602 polymorphism, are linked to an increased risk of atrial fibrillation (AF) in the Chinese Han population. This finding highlights a potential genetic marker for AF susceptibility.

Area of Science:

  • Genetics
  • Cardiology
  • Molecular Biology

Background:

  • Caspase-3 (CASP3) is implicated in atrial fibrillation (AF) pathogenesis.
  • The role of specific CASP3 gene variants in AF susceptibility remains largely unexplored.

Purpose of the Study:

  • To investigate the association between common CASP3 gene variants and the risk of developing AF.
  • To analyze the impact of these genetic variations in the Chinese Han population.

Main Methods:

  • Case-control study involving 889 AF patients and 1015 healthy controls.
  • Genotyping of five CASP3 single nucleotide polymorphisms (SNPs).
  • Statistical analysis including logistic regression to assess risk association.

Main Results:

  • The rs4647602 polymorphism showed a significant difference in genotype distribution between AF patients and controls.
  • A allele frequency for rs4647602 was higher in AF patients (61.0%) versus controls (53.2%).
  • The AA genotype of rs4647602 was associated with significantly increased AF susceptibility (OR=1.84, p<0.001).

Conclusions:

  • The rs4647602 polymorphism is an independent risk factor for AF.
  • This genetic variant is associated with increased susceptibility to atrial fibrillation in the Chinese Han population.
Abstract

Keywords:
ApoptosisAtrial fibrillationCaspase-3GenePolymorphism

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