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Advanced lipid testing: when, why, and in whom?
Karol E Watson1, Eric H Stocker2, Douglas S Jacoby3
1The David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, CA.
Insights
Advanced lipid tests, like low-density lipoprotein particle number, can improve cardiovascular disease risk assessment when standard tests are insufficient. These methods help clinicians better understand patient risk and disease progression.
Area of Science:
- Cardiology
- Biochemistry
Background:
- Atherosclerotic cardiovascular disease (ASCVD) is a major cause of death globally.
- Statin therapy is a cornerstone for preventing ASCVD events in high-risk individuals.
Observation:
- Standard lipid panels adequately assess cardiovascular disease risk for most patients.
- Conventional testing may not fully identify risk or track disease progression in all cases.
Findings:
- Advanced lipid tests offer additional insights beyond standard panels.
- Low-density lipoprotein (LDL) particle number is one such advanced test that can aid risk assessment.
Implications:
- Clinicians can utilize advanced lipid testing to refine cardiovascular risk stratification.
- Improved risk assessment may lead to more personalized and effective prevention strategies for ASCVD.
Abstract:
Atherosclerotic cardiovascular disease is a leading cause of morbidity and mortality in developed countries. The management of blood cholesterol with the use of statin drugs in at-risk patients is a pillar of medical therapy for the primary and secondary prevention of cardiovascular disease. Although the standard lipid panel is adequate to accurately assess cardiovascular disease risk in most patients, there are some situations in which conventional cholesterol testing does not fully identify cardiovascular risk or reflect disease progression. A number of advanced lipid tests can assist the clinician when assessing a patient's cardiovascular disease risk, including measurement of low-density lipoprotein particle number.
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