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Allogeneic donor availability for hematopoietic stem cell transplantation in children with sickle cell disease

David Justus1, Evelio Perez-Albuerne2, Jacqueline Dioguardi2

  • 1School of Medicine and Health Sciences, The George Washington University, Washington, District of Columbia.

Pediatric Blood & Cancer
|February 10, 2015
PubMed

Hematopoietic stem cell transplant is curative of sickle cell disease (SCD) but limited by donor availability. Searches for 85 patients with SCD without matched sibling donors from 2009-2013 using modern techniques (allele-level HLA matching for unrelated donors and higher total nucleated cell doses for umbilical cord blood (UCB)) showed potential match probabilities of 20% for 8/8 HLA-matched unrelated donors, 84% for 7/8 donors, and 97% for two 4-6/6 UCBs suitable for ex-vivo expanded/double cord transplant. Searches performed by age 43 months would have a 90% chance of finding a suitable 5-6/6 UCB.

Keywords:
BMTsickle cell diseasetransplantation

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