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Gold-catalyzed domino reactions
1Chimie ParisTech - CNRS, Institut de Recherche de Chimie Paris, PSL Research University, 75005, Paris, France, veronique-michelet@chimie-paristech.fr.
Gold catalysts enable novel chemical reactions, facilitating complex molecule synthesis. This chapter explores gold-catalyzed domino reactions, including hydration, hydroxylation, and hydroamination, for efficient cascade transformations.
Area of Science:
- Organic Chemistry
- Catalysis
Background:
- Gold catalysis offers unique reactivity for organic synthesis.
- Domino reactions enable efficient construction of complex molecules from simple precursors.
Purpose of the Study:
- To present selected examples of gold-catalyzed domino reactions.
- To highlight hydration, hydroxylation, and hydroamination as key initiating steps for cascade transformations.
- To showcase applications in total synthesis.
Main Methods:
- Utilizing gold catalysts to promote domino reactions.
- Employing 1,n-enynes as substrates for cascade transformations.
- Exploring asymmetric domino transformations.
Main Results:
- Demonstrated the utility of gold catalysis in initiating cascade sequences.
- Showcased the versatility of hydration, hydroxylation, and hydroamination in domino processes.
- Presented successful applications of these domino reactions in total synthesis.
Conclusions:
- Gold-catalyzed domino reactions are powerful tools for constructing complex molecular architectures.
- These cascade processes offer efficient and atom-economical synthetic routes.
- The presented methodologies have significant implications for total synthesis and drug discovery.
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