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Persistent hypotensive effect of L-dopa given early during development to rats with inherited stress-induced arterial
E V Naumenko1, L N Maslova, N I Gordienko
1Institute of Cytology and Genetics, Siberian Department of the Academy of Sciences of the U.S.S.R., Novosibirsk.
Abstract:
A long-lasting decrease of the basal and stress-induced arterial blood pressure was obtained in rats with inherited emotional stress-induced arterial hypertension by means of injections of the dopamine precursor L-DOPA during early development (21-25 days after birth). The restoring effect of L-DOPA was produced through enhancement of synthesis of the brain noradrenaline and, perhaps, adrenaline. The effect was associated with a normalization of the response of the brain adrenergic system to noradrenaline and, presumably, with increase of tyrosine hydroxylase activity in the cortex and hindbrain.