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Author Spotlight: Insights into the Effect of Ischemia Reperfusion on Lung Transplantation
Published on: April 12, 2024
The influence of lung ischemia-reperfusion injury on myocardium
Meng Shi1, Jiechun Huang1, Liewen Pang1
1Department of Cardiothoracic Surgery, Huashan Hospital, Affiliated with Fudan University 12 Wulumuqi Middle Road, Shanghai 200040, China.
Object:
To investigate the effect of lung Ischemia-reperfusion injury on cardiac muscle.
Methods:
SD rats were randomly divided into the following four groups: sham operation group (TS group); experimental control group (TG group); curcumin group (TC group); dexamethasone group (TM group). After 4 h and 24 h of lung ischemia-reperfusion, the cardiac muscle was collected. We measured the concentrations of TNF-α, IL-6, caspase-3, antioxidant capacity and neutrophil infiltration in myocardial tissue.
Results:
After lung ischemia-reperfusion 4 h, TNF-α, IL-6 levels, MDA and neutriphils infiltration increased in myocardial tissue in control group, total antioxidant capacity decreased, and caspase-3 exhibited no significant changes. However, 24 h after reperfusion, there were no significant difference between the sham group and experimental group.
Conclusion:
Lung ischemia-reperfusion injury affected the function of cardiac muscle, especially 4 h after reperfusion. Curcumin and dexamethasone effectively protected myocardial injury after lung ischemia-reperfusion.
