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TLR4 +896A>G (Asp299Gly) polymorphism is not associated with asthma: a update meta-analysis
Yingshui Yao1, Xiaohua Ren2, Lianping He2
1Laboratory of Environment and Health, School of Earth and Environment, Anhui University of Science and Technology Huainan 232001, China ; School of Public Health, Wannan Medical College Wuhu 241002, China.
Abstract:
Some research reported that polymorphisms in the toll-Like receptor 4 may have influence on asthma risk. Here, we sought to estimate the effects of Toll-Like Receptor 4 (Asp299Gly) genes on asthma risk. Databases including PubMed and Chinese National Knowledge Infrastructure (CNKI) databases were searched to find relevant studies. The odds ratio (OR) with corresponding 95% confidence intervals (CIs) was performed. A total of 12 case-control studies were finally identified. This meta-analysis indicated that no significant association was found between TLR4 (Asp299Gly) genes and asthma risk (OR = 0.91, 95% CI = 0.71-1.12). In conclusion, our findings suggest that TLR4 +896A>G (Asp299Gly) polymorphism may not contribute to the risk of asthma.
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