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Updated: Apr 17, 2026

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
Published on: December 10, 2013
Epidemiological and clinical evaluation of children with respiratory virus infections
Somayeh Shatizadeh1, Jila Yavarian2, Farhad Rezaie3
11. MSc, PhD student of Virology, Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. shatizadeh@razi.tums.ac.ir.
Insights
Respiratory viruses are common in young children, with respiratory syncytial virus (RSV) being the most frequent cause of infection. This study identified common respiratory viruses and their characteristics in children under six.
Area of Science:
- Pediatric infectious diseases
- Virology
- Molecular diagnostics
Background:
- Respiratory viruses are a major cause of illness and death in children globally.
- Understanding the epidemiology of these infections is crucial for public health.
Purpose of the Study:
- To detect and identify respiratory viruses in young children with respiratory tract infections.
- To describe the epidemiology and clinical features of these viral infections.
Main Methods:
- A descriptive cross-sectional study involving 202 children under six years old.
- Multiplex PCR was used to analyze throat swabs and wash specimens.
Main Results:
- Respiratory viruses were identified in 92 children.
- Respiratory syncytial virus (RSV) was the most prevalent (16.8%), followed by adenovirus (14.4%).
- Infections showed male predominance, occurred more in children under one year, and were more common in colder months.
Conclusions:
- Nine different respiratory viruses were detected, with RSV being the predominant pathogen.
- Epidemiological patterns were consistent with previous research.
- Clinical presentations were similar across different detected viruses.
Background:
Respiratory viruses are the leading cause of respiratory tract infections among children and are responsible for causing morbidity and mortality worldwide. This study was performed to detect viruses in children with respiratory infections and describe their epidemiology and clinical characteristics.
Methods:
In this descriptive cross sectional study, throat swabs and wash specimens from 202 children younger than six years of age with diagnosis of a respiratory tract infection from a total of 897 specimens were evaluated using multiplex PCR method.
Results:
Respiratory viruses were detected in 92 children: respiratory synsytial virus, 16.8%; influenza virus, 5.4%; parainfluenza virus, 8.4%; adenovirus, 14.4% and human metapneumo virus 0.49% with male predominance and higher distribution in children younger than 1 year of age with preference in the cold months of year. The clinical presentations of all detected viruses were almost similar.
Conclusion:
In the present study, nine different respiratory viruses were detected. RSV causes the great majority of respiratory virus infections in children. There was no significant difference in epidemiologic patterns of these viruses in comparison to other studies.
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