Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antiepileptic Drugs: Potassium Channel Activators01:20

Antiepileptic Drugs: Potassium Channel Activators

1.0K
Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
1.0K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

8.5K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
8.5K
Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

1.7K
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
1.7K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

9.2K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.2K
Antiepileptic Drugs: Glutamate Antagonists01:14

Antiepileptic Drugs: Glutamate Antagonists

1.3K
Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
1.3K
Antiepileptic Drugs: Sodium Channel Blockers01:08

Antiepileptic Drugs: Sodium Channel Blockers

2.5K
Antiepileptic drugs are specialized medications that prevent seizures in individuals diagnosed with epilepsy. These drugs primarily function by blocking the movement of sodium ions through channels in the neuronal membrane, inhibiting the repetitive firing of action potentials often associated with seizures.
Sodium channel blockers modulate ion channels, particularly voltage-gated sodium channels. They block only sodium ion movement.
Among the most commonly prescribed antiepileptic drugs are...
2.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Heterogeneity of psychological resilience among individuals with recurrent implantation failure: a latent profile analysis.

Frontiers in psychiatry·2026
Same author

Heterogeneity of psychological resilience among individuals with recurrent implantation failure: a latent profile analysis.

Frontiers in psychiatry·2026
Same author

Sitz bath with different concentrations of diluted povidone-iodine for prevention of perianal infection in patients with hematological malignancies undergoing chemotherapy: a randomized controlled trial in a tertiary hospital in China.

Frontiers in public health·2026
Same author

Penimeroandranoids A-D, DMOA-Derived Meroterpenoids from the Soil Fungus <i>Penicillium</i> sp. sb62 and Their Bioactivities.

Organic letters·2026
Same author

<i>Hyssopus cuspidatus</i> extract inhibited OVA-sensitized allergic asthma through PI3K/JNK/P38 signaling pathway and lipid homeostasis regulation.

Chinese herbal medicines·2025
Same author

Influencing factors of the implementation of mechanical restraint in open psychiatric ward: a retrospective study (2016-2021).

BMC psychiatry·2025
Same journal

A One-Step Synthesis of <i>β</i>-Bromocodide from Codeine.

Journal of pharmaceutical sciences and pharmacology·2021
Same journal

Molecular Mechanism of <i>β</i>-Catenin Signaling Pathway Inactivation in ETV1-Positive Prostate Cancers.

Journal of pharmaceutical sciences and pharmacology·2017
Same journal

Modulation of Epidermal Growth Factor Stimulated ERK Phosphorylation and Cell Motility by Inositol Trisphosphate Kinase.

Journal of pharmaceutical sciences and pharmacology·2015
Same journal

Ets Related Gene and Smad3 Proteins Collaborate to Activate Transforming Growth Factor-Beta Mediated Signaling Pathway in ETS Related Gene-Positive Prostate Cancer Cells.

Journal of pharmaceutical sciences and pharmacology·2015
Same journal

Molecular Mechanism of Activation of Transforming Growth Factor Beta/Smads Signaling Pathway in Ets Related Gene-Positive Prostate Cancers.

Journal of pharmaceutical sciences and pharmacology·2015
See all related articles

Related Experiment Video

Updated: Apr 17, 2026

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis
12:03

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis

Published on: December 9, 2016

13.0K

Anti-Epileptic Drug Targets Ewing Sarcoma.

Shubhalaxmi Kayarthodi1, Yasuo Fujimura1, Jinbo Fang1

  • 1Cancer Biology Program, Department of OB/GYN, Morehouse School of Medicine, Georgia Cancer Center for Excellence, Grady Memorial Hospital, 80 Jesse Hill Jr. Drive, Atlanta, 30303, GA.

Journal of Pharmaceutical Sciences and Pharmacology
|February 10, 2015
PubMed
Summary
This summary is machine-generated.

Valproic acid (VPA), an anti-epileptic drug, reverses Ewing Sarcoma's EWS-ERG/EWS-Fli-1 oncoprotein effects on RXRα activity. VPA inhibits cancer cell growth, induces apoptosis, and may reduce health disparities in Ewing Sarcoma treatment.

Keywords:
EWS-ERGEWS-Fli-1Ewing SarcomaHistone DeacetylaseRetinoid X Receptor αValproic Acid

More Related Videos

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate
07:31

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

Published on: May 3, 2021

4.5K
Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
09:58

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis

Published on: June 27, 2020

3.2K

Related Experiment Videos

Last Updated: Apr 17, 2026

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis
12:03

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis

Published on: December 9, 2016

13.0K
A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate
07:31

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

Published on: May 3, 2021

4.5K
Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
09:58

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis

Published on: June 27, 2020

3.2K

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Ewing Sarcoma (ES) is a rare pediatric bone cancer driven by chromosomal translocations affecting gene expression.
  • Current ES therapies have significant side effects, necessitating novel therapeutic strategies.
  • Histone acetyl transferases (HATs) and histone deacetylases (HDACs) are key regulators of transcription.

Purpose of the Study:

  • To investigate the molecular mechanism by which EWS-ERG/EWS-Fli-1 fusion proteins regulate RXRα transcriptional activity in ES.
  • To evaluate valproic acid (VPA), an HDAC inhibitor, as a potential therapeutic agent for ES by reversing the inhibitory effects of the fusion protein.

Main Methods:

  • Investigated the interaction between EWS-ERG/EWS-Fli-1 fusion proteins and RXRα transcriptional activity.
  • Utilized valproic acid (VPA) to assess its impact on ES cell lines.
  • Analyzed VPA's effects on cell growth, apoptosis, gene expression (RXRα target genes, fusion proteins), and p21 activity.

Main Results:

  • EWS-ERG/EWS-Fli-1 fusion proteins inhibit RXRα transcriptional activity.
  • VPA effectively reverses the inhibitory effect of EWS-ERG/EWS-Fli-1 on RXRα.
  • VPA treatment inhibits ES cell growth, induces apoptosis, restores RXRα target gene expression, and represses fusion protein levels.

Conclusions:

  • Aberrant fusion proteins in ES regulate HDACs-mediated repressor complexes, inhibiting RXRα activity.
  • VPA demonstrates therapeutic potential by targeting the aberrant fusion protein's mechanism and inhibiting ES cell proliferation.
  • VPA may offer a novel treatment strategy for ES, potentially reducing health disparities.