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Effect of continuous and intermittent clenbuterol feeding on rat growth rate and muscle
M A McElligott1, A Barreto, L Y Chaung
1Merck Sharp & Dohme Research Laboratories, Department of Physiology and Biochemistry, Rahway, NJ 07065.
Abstract:
1. The growth response to clenbuterol is a dynamic process. 2. Body weight gain is stimulated within two days of treatment and the effect attenuates by two weeks of treatment. 3. Intermittent feeding prevents the attenuation of the growth response. 4. Muscle weight increased 14-22% by both feeding regimens. 5. Clenbuterol decreased cathepsin B activity in the EDL and gastrocnemius and increased the activity in the soleus after two weeks of continuous clenbuterol treatment.