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Nuclease resistant oligonucleotides with cell penetrating properties
Stefan Milton1, Dmytro Honcharenko, Cristina S J Rocha
1Karolinska Institutet, Department of Biosciences and Nutrition, Novum, Hälsovägen 7, SE-14183, Huddinge, Sweden. Roger.Stromberg@ki.se.
Chemical Communications (Cambridge, England)
|February 10, 2015
Abstract:
2'-O-AECM modified oligonucleotides provide an unusual combination of remarkable properties. This includes the combination of high resistance towards enzymatic degradation and the spontaneous cellular uptake of AECM oligonucleotides.
