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Tomato paste alters NF-κB and cancer-related mRNA expression in prostate cancer cells, xenografts, and xenograft

Marit Kolberg1, Sigrid Pedersen, Nasser E Bastani

  • 1a Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine , University of Oslo , Oslo , Norway.

Nutrition and Cancer
|February 10, 2015
PubMed

Insights

Tomatoes show biological activity against cancer-related inflammation by modulating nuclear factor-kappa B (NF-κB) signaling. This study investigated tomato paste

Area of Science:

  • Oncology
  • Nutritional Science
  • Molecular Biology

Background:

  • Prostate cancer development may be mitigated by tomatoes, potentially via nuclear factor-kappa B (NF-κB) signaling pathways.
  • Understanding the molecular mechanisms of tomato's chemopreventive potential is crucial.

Purpose of the Study:

  • To investigate the effects of tomato paste on NF-κB activity and cancer-related gene expression in prostate cancer cells and xenografts.
  • To determine if dietary tomato paste influences NF-κB signaling and gene expression in vivo.

Main Methods:

  • Human prostate cancer cells (PC3) with an NF-κB-luciferase construct were treated with tomato extracts.
  • Mice bearing PC3 xenografts were fed a Western-like diet with or without 10% tomato paste.
  • NF-κB activity, gene expression, and lycopene accumulation were analyzed.

Main Results:

  • Tomato diet significantly inhibited TNFα-stimulated NF-κB activity in cultured PC3 cells.
  • Dietary tomato paste modulated genes related to inflammation, apoptosis, and cancer progression in xenografts.
  • Lycopene accumulated in tissues and serum of mice on the tomato diet; NF-κB activity showed a trend toward inhibition in xenografts.

Conclusions:

  • Tomatoes possess biological activity relevant to cancer-related inflammation.
  • Tomato consumption may influence key signaling pathways and gene expression in the tumor microenvironment.
  • Further research into tomato-based cancer prevention strategies is warranted.

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