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Low-Density Lipoprotein Cholesterol Levels and Statin Treatment by HIV Status Among Multicenter AIDS Cohort Study Men

Anne K Monroe1, Wei Fu2, Michelle N Zikusoka3

  • 11Division of General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.

AIDS Research and Human Retroviruses
|February 10, 2015
PubMed

Insights

HIV status did not impact low-density lipoprotein cholesterol (LDL-c) target achievement in men on statin therapy. Comorbidities like diabetes were linked to not meeting LDL-c goals.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Public Health

Background:

  • Cardiovascular disease (CVD) risk factor management is crucial in human immunodeficiency virus (HIV) care.
  • Dyslipidemia, characterized by abnormal blood lipid levels, requires effective control.
  • Achieving low-density lipoprotein cholesterol (LDL-c) targets serves as a metric for dyslipidemia management, though its universal adoption is debated.

Purpose of the Study:

  • To investigate the association between HIV serostatus and the failure to achieve LDL-c targets.
  • To identify predictors of not meeting LDL-c goals in both HIV-infected and HIV-uninfected individuals.

Main Methods:

  • Analysis of data from the Multicenter AIDS Cohort Study (MACS) visit 56 (October 1, 2011–March 31, 2012).
  • Participants were categorized based on HIV status and statin therapy use.
  • LDL-c target achievement was assessed using NCEP ATP III guidelines.
  • Multivariate logistic regression was employed to determine associated factors.

Main Results:

  • No significant difference was observed in LDL-c target non-achievement between HIV-infected and HIV-uninfected men not on statin therapy (11.1% vs. 14.9%, p=0.07).
  • Similarly, rates of LDL-c target non-achievement were comparable for HIV-infected and HIV-uninfected men on statin therapy (13.5% vs. 14.2%, p=0.82).
  • Predictors for not achieving LDL-c targets included current smoking, hypertension (without statins), and diabetes (with statins).

Conclusions:

  • HIV serostatus is not independently associated with failing to meet LDL-c targets when patients are on statin therapy.
  • The presence of comorbidities, such as diabetes, significantly influences the ability to achieve LDL-c targets.
  • These findings underscore the importance of managing comorbidities in lipid management strategies for all individuals, including those with HIV.

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