[Inferior colliculus stimulation effects in KrushinskiI-Molodkina strain rats]

The effects of the central nucleus of the inferior colliculus chemical and electrical stimulation on the producing and forming the convulsive manifestations, as well as on the organization of sleep, was studied in Krushinskii-Molodkina strain rats, which have an inherited predisposition to audiogenic seizures. Microinjections of quinolinic acid (10 micrograms) or electrical stimulation with 70 Hz frequency produced the paroxysmal manifestations in the form of intensive circular excursions coincident wild running behaviors on the initial nonseizures motor exitation stage of audiogenic seizures. The results suggest that in Krushinskii-Molodkina strain rats the inferior colliculus is involved in the neuronal network, responsible for initiation and realization to the scampering stage of the evoked convulsive reactions to sound. The reduction of fast-wave (paradoxical) sleep total duration after the given actions it was observed. However, the inferior colliculus electrical stimulation with 7 Hz frequency during slow-wave sleep cause appearance the episodes fast-wave sleep. A significant (almost twice due) increase of the total time of fast-wave sleep by increasing the quantity, but not the duration of these episodes after 3-4 sessions of such sort stimulations were observed. These results showed that the inferior colliculus rats can produce the modulating action on the brain system responsible for triggering fast-wave sleep.