Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

1.2K
Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
1.2K
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

1.5K
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.5K
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

4.8K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
4.8K
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

1.5K
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
1.5K
Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

611
Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
611
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

668
Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
668

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transforming post-STEMI care: The IMPACS study design and baseline patient profile.

International journal of cardiology·2026
Same author

Recombination of HCO+ ions with electrons in the temperature range of 80-200 K.

The Journal of chemical physics·2025
Same author

Ultrasound detection of non-atherosclerotic intima-medial abnormalities of lower limbs arteries in amateur endurance runners.

Journal of ultrasound·2024
Same author

In-vitro antiplatelet effect of melatonin in healthy individuals and patients with type 2 diabetes mellitus.

Journal of endocrinological investigation·2023
Same author

Single centre 12 year experience with durable mechanical circulatory support: comparison with the EUROMACS registry.

Bratislavske lekarske listy·2021
Same author

Altered serum levels of neprilysin in heart failure patients with reduced ejection fraction.

Bratislavske lekarske listy·2021

Related Experiment Video

Updated: Apr 17, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.9K

Functional and circulatory renal changes in advanced heart failure.

E Demesova, E Goncalvesova, P Slezak

    Bratislavske Lekarske Listy
    |February 11, 2015
    PubMed
    Summary

    In heart failure patients, left and right ventricular functions significantly impact renal function. Cardiac output and right atrial pressure did not show associations with renal function in stable patients.

    Area of Science:

    • Cardiology
    • Nephrology
    • Internal Medicine

    Background:

    • Heart failure commonly leads to impaired renal function, a condition known as cardiorenal syndrome.
    • Understanding the interplay between cardiac and renal health is crucial for managing chronic heart failure patients.

    Purpose of the Study:

    • To elucidate the relationship between cardiac and renal functions in heart failure patients.
    • To determine if reduced glomerular filtration rate is primarily driven by diminished perfusion or venous congestion.

    Main Methods:

    • A prospective cohort study involving 101 patients with chronic heart failure.
    • Analysis included blood samples, echocardiography, and right heart catheterization data.

    Main Results:

    More Related Videos

    Multilevel Microdissection and Functional-Structural Profiling of Human Renal Arterial Branches
    06:51

    Multilevel Microdissection and Functional-Structural Profiling of Human Renal Arterial Branches

    Published on: September 5, 2025

    769
    A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
    07:52

    A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

    Published on: November 7, 2017

    22.5K

    Related Experiment Videos

    Last Updated: Apr 17, 2026

    Assessment of Vascular Function in Patients With Chronic Kidney Disease
    08:50

    Assessment of Vascular Function in Patients With Chronic Kidney Disease

    Published on: June 16, 2014

    16.9K
    Multilevel Microdissection and Functional-Structural Profiling of Human Renal Arterial Branches
    06:51

    Multilevel Microdissection and Functional-Structural Profiling of Human Renal Arterial Branches

    Published on: September 5, 2025

    769
    A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
    07:52

    A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

    Published on: November 7, 2017

    22.5K
    • Left ventricular ejection fraction showed a correlation with estimated glomerular filtration rate (eGFR).
    • Cardiac output correlated with renal perfusion pressure in the entire patient cohort and specifically in those with chronic heart failure.
    • Mean pulmonary artery pressure (PAP) was associated with renal function variables, including renal perfusion pressure and eGFR.

    Conclusions:

    • In heart failure patients, both left and right ventricular functions are key determinants of renal function.
    • In advanced but stable heart failure, markers of renal perfusion like cardiac output and right atrial pressure were not significantly associated with renal function.