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Improving Translational Accuracy

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Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...

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A peer-led mock OSCE improves subsequent performance: What about objectivity?

Alexander Fletcher¹, Richard Day¹

¹a University of Dundee , Dundee , Scotland.

Medical Teacher

|February 11, 2015

Summary

No abstract available in PubMed .

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