High-sensitivity C-reactive protein predicts adverse cardiovascular events in patients with Takayasu arteritis with

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X Wang1, A Dang2, N Lv1

  • 1State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing, 100037, China.

Clinical Rheumatology
|February 11, 2015
PubMed

Insights

High-sensitivity C-reactive protein (hsCRP) predicts major adverse cardiovascular events (MACE) in Takayasu arteritis (TA) patients with coronary artery disease (CAD). Elevated hsCRP levels are an independent risk factor for cardiovascular events in this population.

Area of Science:

  • Cardiology
  • Immunology
  • Vascular Biology

Background:

  • Takayasu arteritis (TA) is a large vessel vasculitis that can affect the coronary arteries, leading to coronary artery disease (CAD).
  • Assessing cardiovascular risk in TA patients with CAD is crucial for timely intervention and improved outcomes.
  • Biomarkers such as high-sensitivity C-reactive protein (hsCRP) and N-terminal pro-brain natriuretic peptide (NT-proBNP) may offer prognostic value.

Purpose of the Study:

  • To evaluate the association between hsCRP and NT-proBNP levels and the occurrence of major adverse cardiovascular events (MACE) in patients with TA and concomitant CAD.
  • To identify independent predictors of MACE in this specific patient cohort.

Main Methods:

  • Retrospective analysis of 60 TA patients with CAD and 60 matched CAD patients without TA.
  • Data collected included clinical features, laboratory results, coronary angiographic findings, treatments, and follow-up outcomes.
  • MACE were defined as cardiac death, myocardial infarction, target vessel revascularization, or rehospitalization for unstable/progressive angina.

Main Results:

  • CAD patients without TA exhibited more atherogenic lipid profiles (lower HDL-C, higher LDL-C) compared to TA-CAD patients.
  • During a mean follow-up of 3.2 years, 31 TA-CAD patients experienced MACE.
  • Multivariate analysis identified elevated baseline hsCRP levels as a significant and independent predictor of MACE (HR=5.3, p=0.04) in TA-CAD patients.

Conclusions:

  • Elevated hsCRP levels are a strong independent predictor of cardiovascular events in patients with TA-related CAD.
  • hsCRP may serve as a valuable prognostic marker for risk stratification in TA patients with coronary artery disease.
  • Further research could explore the therapeutic implications of targeting inflammation, as indicated by hsCRP, in TA-CAD management.

Keywords:
NT-proBNPPrognosisTakayasu arteritishsCRP

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