Related Experiment Video
Updated: Apr 17, 2026

Transduction and Expansion of Primary T Cells in Nine Days with Maintenance of Central Memory Phenotype
Published on: March 18, 2020
Integrating Vitamin A Supplementation at 6 months into the Expanded Program of Immunization in Sierra Leone
Mary H Hodges1, Fatmata F Sesay, Habib I Kamara
1Helen Keller International Sierra Leone, P.O. Box 369, Freetown, Sierra Leone, mhodges@hki.org.
Insights
Integrating vitamin A supplementation (VAS) into routine immunizations improved early access for infants. Combining VAS with infant feeding and family planning services further increased coverage and uptake.
Area of Science:
- Public Health
- Pediatrics
- Nutrition
Background:
- Twice-yearly mass vitamin A supplementation (VAS) in Sierra Leone reaches most children but creates delays for infants turning six months between campaigns.
- Integrating VAS into the Expanded Program of Immunization (EPI) at six months could improve timely delivery.
Purpose of the Study:
- To evaluate the effectiveness of integrating VAS into the EPI schedule using a revised child health card.
- To assess the impact of adding infant and young child feeding (IYCF) and family planning (FP) services to integrated VAS delivery.
Main Methods:
- A study compared three groups: a 'mini package' (VAS + IYCF), a 'full package' (VAS + IYCF + FP), and 'child health card' only.
- 400 neonates were enrolled in each group and followed until 12 months of age.
Main Results:
- Infants in the 'full' (74.5%) and 'mini' (71.7%) groups received VAS between 6-7 months significantly more often than the 'child health card' only group (60.2%).
- Family planning commodities were provided to 44.5% of caregivers in the 'full' package group versus <2.5% in others.
- Integrated VAS within EPI achieved over 60% coverage for infants aged 6-7 months, with added services improving uptake.
Conclusions:
- Integrating vitamin A supplementation into the EPI schedule is an effective strategy to improve timely delivery to infants.
- Combining VAS with IYCF and FP services enhances service delivery and coverage for maternal and child health interventions.
Abstract:
Since 2004, twice-yearly mass vitamin A supplementation (VAS) has equitably reached over 85% of children 6-59 months old in Sierra Leone. However infants who turn 6 months after the event may wait until they are 11 months old to receive their first dose. The effectiveness of integrating VAS at 6 months into the Expanded Program of Immunization (EPI) in a revised child health card was studied. Health facilities matched according to staff cadre and work load were assigned to provide either a 'mini package' of VAS and infant and young child feeding (IYCF), a 'full package' of VAS, IYCF and family planning (FP), or 'child health card' only. 400 neonates were enrolled into each group, caregivers given the new child health card and followed until they were 12 months old. More infants in the full: 74.5% and mini: 71.7% group received VAS between 6 and 7 months of age compared with the new CH card only group: 60.2% (p = 0.002, p < 0.001 respectively). FP commodities were provided to 44.5% of caregivers in the full compared with <2.5% in the mini and new child health card only groups (p < 0.0001). Integration of VAS within the EPI schedule achieved >60% coverage for infants between 6 and 7 months of age. Provision of FP and/or IYCF further improved coverage. Funding was provided by the Canadian Department of Foreign Affairs, Trade and Development who had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.
Related Concept Videos
Development of Immunocompetence
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Immunodeficiency Diseases
There are three main causes of immunodeficiency...
Vaccinations
Pulmonary Tuberculosis IV
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...