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Childhood functional abdominal pain: mechanisms and management

Judith Korterink1, Niranga Manjuri Devanarayana2, Shaman Rajindrajith2

  • 1Department of Paediatric Gastroenterology &Nutrition, Emma Children's Hospital, Academic Medical Centre, Meibergdreef 9, 1105 AZ, Amsterdam, Netherlands.

Nature Reviews. Gastroenterology & Hepatology
|February 11, 2015
PubMed

Insights

Chronic abdominal pain in children is common but poorly understood. This review covers its causes, diagnosis, and treatments, including diet and therapies, to improve care.

Area of Science:

  • Pediatric Gastroenterology
  • Clinical Medicine

Background:

  • Chronic abdominal pain is a frequent pediatric clinical syndrome.
  • Its definition, predisposing factors, and pathophysiology remain unclear.
  • Diagnosis is challenging due to the need to exclude organic causes and lack of high-quality trials.

Purpose of the Study:

  • To review current knowledge on the epidemiology, pathophysiology, risk factors, and diagnostic work-up of functional abdominal pain in children.
  • To discuss management options for improving care.

Main Methods:

  • Literature review summarizing existing research.
  • Discussion of diagnostic approaches and therapeutic interventions.

Main Results:

  • Functional abdominal pain pathogenesis likely involves hypersensitivity and altered motility.
  • Evidence-based treatment is limited by a lack of large clinical trials.
  • Management strategies include medications, dietary changes, probiotics, and psychological/complementary therapies.

Conclusions:

  • Further research is needed to clarify pathophysiology and conduct high-quality trials.
  • A comprehensive approach integrating medical, dietary, and psychological interventions is crucial for managing pediatric functional abdominal pain.

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