Target based drug design - a reality in virtual sphere
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Updated: Apr 17, 2026

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
Published on: December 1, 2020
Saroj Verma, Yenamandra S Prabhakar1
1Medicinal and Process Chemistry Division, Academy of Scientific and Innovative Research, CSIRCentral Drug Research Institute, Sector-10 Jankipuram Extension, Sitapur Road, Lucknow - 226031, India. yenpra@yahoo.com.
Abstract:
The target based drug design approaches are a series of computational procedures, including visualization tools, to support the decision systems of drug design/discovery process. In the essence of biological targets shaping the potential lead/drug molecules, this review presents a comprehensive position of different components of target based drug design which include target identification, protein modeling, molecular dynamics simulations, binding/catalytic sites identification, docking, virtual screening, fragment based strategies, substructure treatment of targets in tackling drug resistance, in silico ADMET, structural vaccinology, etc along with the key issues involved therein and some well investigated case studies. The concepts and working of these procedures are critically discussed to arouse interest and to advance the drug research.
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