Are androgen receptor variants a substitute for the full-length receptor?

Related Experiment Video

Updated: Apr 17, 2026

Detecting the Ligand-binding Domain Dimerization Activity of Estrogen Receptor Alpha Using the Mammalian Two-Hybrid Assay
09:07

Detecting the Ligand-binding Domain Dimerization Activity of Estrogen Receptor Alpha Using the Mammalian Two-Hybrid Assay

Published on: December 19, 2018

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Ji Lu1, Travis Van der Steen2, Donald J Tindall3

  • 1Department of Urology, First Hospital of Jilin University, 71 Xinmin Street, Changchun 130021, China.

Nature Reviews. Urology
|February 11, 2015
PubMed

Insights

Androgen receptor splice variants (AR-Vs) are active in prostate cancer and resist treatment. Targeting AR-Vs may offer a new therapeutic strategy for castration-resistant prostate cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Urology

Background:

  • Androgen receptor splice variants (AR-Vs) are present in castration-resistant prostate cancer (CRPC).
  • AR-Vs lack the ligand-binding domain, leading to constitutive activity.
  • These variants are resistant to conventional androgen deprivation therapy (ADT).

Purpose of the Study:

  • To investigate the role of AR-Vs in CRPC.
  • To explore AR-Vs as a potential therapeutic target.

Main Methods:

  • Analysis of AR-V expression in CRPC cell lines and clinical samples.
  • Characterization of AR-V activity and resistance mechanisms.

Main Results:

  • AR-Vs are expressed in CRPC.
  • Constitutive activity of AR-Vs contributes to ADT resistance.
  • AR-V induction can be triggered by ADT.

Conclusions:

  • AR-Vs are key drivers in CRPC progression and treatment resistance.
  • Targeting AR-Vs presents a promising therapeutic avenue for advanced prostate cancer.

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