Related Experiment Video

Updated: Apr 17, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

9.9K

[Lipoprotein(a): influence on cardiovascular manifestation]

K-P Mellwig1, C Schatton, B Biermann

  • 1Klinik für Kardiologie, Herz- und Diabeteszentrum NRW, Universitätsklinik der Ruhr-Universität Bochum, Georgstr. 11, 32545, Bad Oeynhausen, Deutschland, kpmellwig@hdz-nrw.de.

Clinical Research in Cardiology Supplements
|February 11, 2015
PubMed

Insights

High lipoprotein(a) (Lp(a)) levels significantly increase the risk and severity of coronary artery disease (CAD). This study found that elevated Lp(a) is a strong independent predictor of advanced CAD, irrespective of other risk factors.

Area of Science:

  • Cardiology
  • Lipidology
  • Genetics

Context:

  • Lipoprotein(a) (Lp(a)) is an established, yet often underestimated, independent risk factor for cardiovascular disease.
  • The clinical significance of elevated Lp(a) in the development and progression of coronary artery disease (CAD) requires further elucidation.

Purpose:

  • To investigate the association between increased lipoprotein(a) concentrations and the prevalence and severity of coronary artery disease.
  • To compare CAD outcomes in patients with varying Lp(a) levels, including those with isolated elevations and those with co-existing risk factors like elevated LDL cholesterol and HbA1c.

Summary:

  • A retrospective analysis of 31,274 patients revealed that individuals with high Lp(a) levels (≥ 110 mg/dl) exhibited a significantly higher incidence of advanced CAD, including three-vessel disease.
  • Patients with elevated Lp(a) had a substantially greater history of myocardial infarction, coronary artery bypass grafting, and percutaneous coronary intervention compared to those with normal Lp(a) levels.
  • The study indicated a 5.5-fold increased CAD risk in patients with Lp(a) ≥ 110 mg/dl, with no additional adverse impact from elevated LDL cholesterol or HbA1c.

Impact:

  • This research underscores the critical role of Lp(a) as a potent driver of CAD development and severity, independent of other common risk factors.
  • Findings highlight the need for increased clinical awareness and potential therapeutic strategies targeting Lp(a) to mitigate cardiovascular risk.
  • The study also noted a gender disparity, with male patients being disproportionately affected by Lp(a)-related CAD.

More Related Videos

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation06:47

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Published on: January 28, 2021

12.8K
Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

15.2K

Related Concept Videos

Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
613
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
2.2K
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
877
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
646
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
2.1K
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
1.9K