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Related Experiment Video

Updated: Jan 23, 2026

A Piglet Perinatal Asphyxia Model to Study Cardiac Injury and Hemodynamics after Cardiac Arrest, Resuscitation, and the Return of Spontaneous Circulation
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Who should we cool after perinatal asphyxia?

Marianne Thoresen1

  • 1Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway; Neonatal Neuroscience, School of Clinical Sciences, University of Bristol, Bristol, UK.

Seminars in Fetal & Neonatal Medicine
|February 11, 2015
PubMed
Summary

Therapeutic hypothermia (TH) is standard care for newborns with perinatal asphyxia, but challenges remain in selecting infants, optimizing cooling, and tracking long-term outcomes. This review examines patient selection and management strategies for TH.

Keywords:
Clinical trialFollow-upHumanHypoxic–ischemic encephalopathyInclusion criteriaTherapeutic hypothermia

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Area of Science:

  • Neonatal Medicine
  • Pediatric Neurology
  • Critical Care

Background:

  • Therapeutic hypothermia (TH) is a standard treatment for term newborns experiencing perinatal asphyxia.
  • Despite its established role, challenges persist in optimizing its application and evaluating long-term effectiveness.

Purpose of the Study:

  • To review and address ongoing challenges in the implementation of TH for neonatal perinatal asphyxia.
  • To discuss patient selection criteria and management strategies for TH delivery.

Main Methods:

  • Literature review focusing on entry criteria, patient selection, and management protocols for TH.
  • Analysis of issues related to cooling intensity, timing, and application in diverse neonatal populations.

Main Results:

  • Identifies key challenges in ensuring appropriate infant cooling and optimizing TH delivery based on encephalopathy severity.
  • Discusses the complexities of applying TH to infants outside standard criteria, including those with comorbidities.

Conclusions:

  • Refining patient selection and management protocols is crucial for maximizing the efficacy of TH.
  • Further research is needed for systematic long-term follow-up and standardized outcome data collection across centers.