Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cross-reactivity

Cross-reactivity

Retrovirus Life Cycles

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[HER2 promotes cell migration via inhibiting the expression of E-cadherin in human mammary epithelial cells].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology·2017

Same author

Benefits of a right anterolateral minithoracotomy rather than a median sternotomy in isolated tricuspid redo procedures.

Journal of thoracic disease·2017

Same author

Suppression of cucumber stachyose synthase gene (CsSTS) inhibits phloem loading and reduces low temperature stress tolerance.

Plant molecular biology·2017

Same author

Prognostic Factors for Recovery of Patients After Surgery for Thoracic Spinal Tuberculosis.

World neurosurgery·2017

Same author

NaK alloy-induced in vivo tumor ablation therapy.

Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy·2017

Same author

Robust Granger Analysis in Lp Norm Space for Directed EEG Network Analysis.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society·2017

Search research articles

Related Experiment Video

Updated: Apr 17, 2026

Utilizing the Antigen Capsid-Incorporation Strategy for the Development of Adenovirus Serotype 5-Vectored Vaccine Approaches

Utilizing the Antigen Capsid-Incorporation Strategy for the Development of Adenovirus Serotype 5-Vectored Vaccine Approaches

Published on: May 6, 2015

Receptor binding domain based HIV vaccines.

Huan Liu¹, Wenwen Bi², Qian Wang²

¹State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Xiaohongshan 44, Wuhan 430071, China.

Biomed Research International

|February 11, 2015

Summary

Developing an effective acquired immunodeficiency syndrome (AIDS) vaccine is challenging. This research focuses on the gp120 receptor binding domain to create a potent and broad AIDS vaccine candidate.

More Related Videos

Assessment of Immunologically Relevant Dynamic Tertiary Structural Features of the HIV-1 V3 Loop Crown R2 Sequence by ab initio Folding

Assessment of Immunologically Relevant Dynamic Tertiary Structural Features of the HIV-1 V3 Loop Crown R2 Sequence by ab initio Folding

Published on: September 15, 2010

Conformational Evaluation of HIV-1 Trimeric Envelope Glycoproteins Using a Cell-based ELISA Assay

Conformational Evaluation of HIV-1 Trimeric Envelope Glycoproteins Using a Cell-based ELISA Assay

Published on: September 14, 2014

Related Experiment Videos

Last Updated: Apr 17, 2026

Utilizing the Antigen Capsid-Incorporation Strategy for the Development of Adenovirus Serotype 5-Vectored Vaccine Approaches

Utilizing the Antigen Capsid-Incorporation Strategy for the Development of Adenovirus Serotype 5-Vectored Vaccine Approaches

Published on: May 6, 2015

Assessment of Immunologically Relevant Dynamic Tertiary Structural Features of the HIV-1 V3 Loop Crown R2 Sequence by ab initio Folding

Assessment of Immunologically Relevant Dynamic Tertiary Structural Features of the HIV-1 V3 Loop Crown R2 Sequence by ab initio Folding

Published on: September 15, 2010

Conformational Evaluation of HIV-1 Trimeric Envelope Glycoproteins Using a Cell-based ELISA Assay

Conformational Evaluation of HIV-1 Trimeric Envelope Glycoproteins Using a Cell-based ELISA Assay

Published on: September 14, 2014

Area of Science:

Immunology
Vaccinology
Virology

Background:

Developing an effective vaccine against human immunodeficiency virus type 1 (HIV-1) remains a significant global health challenge.
Despite extensive research, achieving robust protection against HIV-1 infection through vaccination has proven difficult.

Purpose of the Study:

To analyze recent trends in acquired immunodeficiency syndrome (AIDS) vaccine development.
To identify the receptor binding domain of gp120 as a promising target for novel AIDS vaccine design.
To propose strategies for inducing cross-reactive neutralizing antibodies with high binding affinity.

Main Methods:

Review and analysis of current trends in AIDS vaccine research.
Focus on the structural and functional properties of the gp120 receptor binding domain.
Exploration of immunogenic approaches to elicit potent antibody responses.

Main Results:

The gp120 receptor binding domain is highlighted as a key target for AIDS vaccine development.
Specific measures are recommended for enhancing the induction of neutralizing antibodies.
The proposed strategies aim to improve antibody affinity and cross-reactivity.

Conclusions:

Targeting the gp120 receptor binding domain offers a viable strategy for developing effective AIDS vaccines.
Inducing high-affinity, cross-reactive neutralizing antibodies is crucial for vaccine potency.
These findings may pave the way for new research and development in broad-spectrum AIDS vaccines.