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Single-Strand DNA Binding Proteins

Single-Strand DNA Binding Proteins

For successful DNA replication, the unwinding of double-stranded DNA must be accompanied by stabilization and protection of the separated single strands of the DNA. This crucial task is performed by single-strand DNA-binding (SSB) proteins. They bind to the DNA in a sequence-independent manner, which means that the nitrogenous bases of the DNA need not be present in a specific order for binding of SSB proteins to it. The binding of SSB proteins straightens single-stranded DNA (ssDNA) and makes...

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Updated: Apr 17, 2026

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

A dynamic combinatorial approach for identifying side groups that stabilize DNA-templated supramolecular

Delphine Paolantoni¹, Sonia Cantel², Pascal Dumy³

¹Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS-Université de Montpellier, ENSCM, Ecole Nationale Supérieure de Chimie de Montpellier, 8 Rue de l'Ecole Normale, Montpellier Cedex 5 34296, France. delphine.paolantoni@enscm.fr.

International Journal of Molecular Sciences

|February 11, 2015

Summary

Researchers explored DNA-templated self-assembly using guanidinium compounds. Aromatic and cationic side groups were found to stabilize these DNA-supramolecular complexes through secondary interactions.

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Last Updated: Apr 17, 2026

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Area of Science:

Supramolecular Chemistry
Biomolecular Engineering

Background:

DNA-templated self-assembly is a promising strategy for creating functional supramolecular systems.
Bis-functionalized guanidinium compounds can form supramolecular complexes with single-stranded DNA (ssDNA) by recognizing its phosphodiester backbone.

Purpose of the Study:

To investigate the role of secondary interactions in stabilizing DNA-supramolecular assemblies.
To identify specific side groups that enhance the stability of these complexes.

Main Methods:

Implementation of a dynamic combinatorial approach using in situ fragment assembly.
Utilized reductive amination for compound synthesis.
Tested various side groups, including amino acids, for their effect on complex stability.

Main Results:

Aromatic and cationic side groups were identified as key contributors to secondary supramolecular interactions.
These interactions significantly stabilize the supramolecular complexes formed between guanidinium compounds and ssDNA.
The study highlights the importance of tailored side groups for robust DNA-templated self-assembly.

Conclusions:

Tailoring side groups on guanidinium compounds is crucial for enhancing the stability of DNA-templated supramolecular assemblies.
Aromatic and cationic moieties promote secondary interactions that strengthen the DNA-ligand complex.
This work provides insights for designing advanced functional supramolecular systems based on DNA recognition.