Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Nitrogen Metabolism01:20

Overview of Nitrogen Metabolism

12.7K
Nitrogen is a very important element for life because it is a major constituent of proteins and nucleic acids. It is a macronutrient, and in nature, it is recycled from organic compounds and stored in the form of  ammonia, ammonium ions, nitrate, nitrite, or  nitrogen gas by many metabolic processes. Many of these metabolic processes are carried out only by prokaryotes.
The largest pool of nitrogen available in the terrestrial ecosystem is gaseous nitrogen (N2) from the air, but this...
12.7K
Physical Principles Governing Gas Exchange01:16

Physical Principles Governing Gas Exchange

4.7K
Gas behavior plays a vital role in understanding bodily processes such as external and internal respiration. External respiration involves the diffusion of oxygen into the blood and carbon dioxide out of it in the lungs. In contrast, internal respiration happens in body tissues, where these gases move in opposite directions.
Gas Laws Governing Respiration
The behavior of gases is guided by Dalton's Law of partial pressures and Henry's Law.
Dalton's Law asserts that the total...
4.7K
The Nitrogen Cycle01:49

The Nitrogen Cycle

61.6K
Nitrogen atoms, present in all proteins and DNA, are recycled between abiotic and biotic components of the ecosystem. However, the primary form of nitrogen on Earth is nitrogen gas, which cannot be used by most animals and plants. Thus, nitrogen gas must first be converted into a usable form by nitrogen-fixing bacteria before it can be cycled through other living organisms. The use of nitrogen-containing fertilizers and animal waste products in human agriculture has greatly influenced the...
61.6K
Physiological Control of Respiration01:23

Physiological Control of Respiration

7.1K
Introduction
Breathing, a seemingly passive process, is regulated by the respiratory center in the brainstem. This center coordinates the involuntary control of respirations, which means it occurs without conscious effort, ensuring a smooth and uninterrupted pattern.
Regulation of Ventilation
The body maintains ventilation by monitoring levels of carbon dioxide (CO2), oxygen (O2), and hydrogen ion concentration (pH) in the arterial blood. Among these factors, the level of CO2 plays a crucial...
7.1K
Gross Anatomy of the Lungs01:17

Gross Anatomy of the Lungs

6.6K
The lungs are a pair of vital organs connected to the trachea via the left and right bronchi. The base of these organs meets the dome-shaped muscle known as the diaphragm. Encased by the pleurae, the lungs contact the mediastinum. The right lung is shorter yet wider, and has a larger volume than the left lung. The left lung has an indentation known as the cardiac notch. The superior region of the lungs is referred to as the apex, whereas the base is the lower region near the diaphragm. The...
6.6K
Physiology of Respiration I: Functions of the Respiratory System01:27

Physiology of Respiration I: Functions of the Respiratory System

5.8K
The respiratory system is crucial for exchanging oxygen (O2) and carbon dioxide (CO2) between the atmosphere and the bloodstream, maintaining the body's balance. Beyond gas exchange, it helps regulate acid-base balance, purify inhaled air, and enable vocalization.
Fundamental Processes in Respiration:
5.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bronchoscopic evaluation of human airway surface liquid pH.

American journal of respiratory and critical care medicine·2026
Same author

A novel antiviral strategy targeting human metapneumovirus through pH modulation in human airway epithelial cells.

The Journal of general virology·2026
Same author

A Novel PCD Phenotype: Inherent Mucus Hypersecretion by Patient-Derived Airway Epithelial Cells.

Pediatric pulmonology·2026
Same author

Comparison of methods for isolation of extracellular vesicles from bronchoalveolar lavage fluid.

Extracellular vesicles and circulating nucleic acids·2026
Same author

Dehydroepiandrosterone increases airway epithelial cell pH in asthma patients.

American journal of respiratory cell and molecular biology·2026
Same author

Asthma and inhaled corticosteroids in primary ciliary dyskinesia (PCD): a consensus from the Minneapolis PCD meeting.

American journal of respiratory and critical care medicine·2026

Related Experiment Video

Updated: Apr 17, 2026

A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects
05:46

A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects

Published on: May 4, 2021

5.9K

Nitrogen chemistry and lung physiology.

Nadzeya V Marozkina1, Benjamin Gaston

  • 1Department of Pediatrics, Rainbow Babies and Children's Hospital and Case Western Reserve University, Cleveland, Ohio 44106; email: Nadzeya.marozkina@case.edu , Benjamin.gaston@case.edu.

Annual Review of Physiology
|February 11, 2015
PubMed
Summary

Nitrogen

Area of Science:

  • Pulmonary Physiology
  • Biochemistry
  • Cell Signaling

Background:

  • Nitrogen's diverse chemistry impacts lung function and disease.
  • Various redox states of nitrogen are crucial in pulmonary biology.
  • Oxidized nitrogen species, particularly S-nitrosothiols, play key roles in lung cell signaling.

Purpose of the Study:

  • To review the significance of different nitrogen forms in pulmonary physiology.
  • To highlight the role of oxidized nitrogen, especially S-nitrosothiols, in lung cell signaling.
  • To explore clinical applications of nitrogen oxide biochemistry in pulmonary diseases.

Main Methods:

  • Literature review of nitrogen chemistry in pulmonary biology.
  • Focus on oxidized nitrogen species and S-nitrosothiols.
Keywords:
S-nitrosylationasthmacystic fibrosisdenitrificationlung ecologynitric oxidepulmonary hypertension

More Related Videos

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds
08:23

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds

Published on: February 16, 2022

5.0K
Author Spotlight: Integrating Alveolar-Capillary Reserve Measurements in Exercise Adaptation and Therapeutic Strategies
08:44

Author Spotlight: Integrating Alveolar-Capillary Reserve Measurements in Exercise Adaptation and Therapeutic Strategies

Published on: February 2, 2024

1.5K

Related Experiment Videos

Last Updated: Apr 17, 2026

A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects
05:46

A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects

Published on: May 4, 2021

5.9K
Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds
08:23

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds

Published on: February 16, 2022

5.0K
Author Spotlight: Integrating Alveolar-Capillary Reserve Measurements in Exercise Adaptation and Therapeutic Strategies
08:44

Author Spotlight: Integrating Alveolar-Capillary Reserve Measurements in Exercise Adaptation and Therapeutic Strategies

Published on: February 2, 2024

1.5K
  • Examination of clinical applications and translation to practice.

    • Main Results:

    • Elemental, reduced, and oxidized nitrogen forms are relevant to lung physiology and pathophysiology.
    • S-nitrosothiols are integral to lung cell-signaling pathways.
    • Nitrogen oxide biochemistry offers potential for diagnostics and therapies.

    Conclusions:

    • Nitrogen chemistry, especially oxidized forms like S-nitrosothiols, is fundamental to lung function and cell signaling.
    • Understanding nitrogen oxide biochemistry can lead to novel treatments for pulmonary conditions.
    • Clinical translation of these principles is advancing for diseases such as asthma and pulmonary hypertension.