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Updated: Apr 17, 2026
Compact Quantum Dots for Single-molecule Imaging
Published on: October 9, 2012
Quantum dots encapsulated glycopolymer vesicles: synthesis, lectin recognition and photoluminescent properties
Danfeng Pei1, Yanchun Li2, Qingrong Huang3
1State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China.
Abstract:
Biomimetic star-shaped glycopolymer poly(ɛ-caprolactone)-b-poly(2-aminoethyl methacrylate-b-poly(gluconamidoethylmethacrylate) (SPCL-PAMA-PGAMA) was synthesized by the combination of ring opening polymerization (ROP) and reversible addition-fragmentation chain transfer (RAFT) polymerization. The glycopolymer self-assembled into vesicles with low critical aggregation concentration (CAC) (0.0075 mg/mL). Then, the carboxylic capped CdTe QDs were encapsulated within the glycopolymer vesicles. The QDs encapsulated glycopolymer vesicles (Gly@QDs vesicles) could specifically bind Concanavalin A (Con A) without changing the photoluminescent properties of the Gly@QDs vesicles. Cell viability studies revealed that the cytotoxicity of the Gly@QDs vesicles was remarkably improved as compared to that of the original QDs. The Gly@QDs vesicles were internalized by Hep G2 cells and then emitted green fluorescence in the cells. Consequently, these Gly@QDs vesicles provided a multifunctional platform for targeted delivery and imaging.
