Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

2.1K
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
2.1K
Common Ion Effect03:24

Common Ion Effect

48.5K
Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Châtelier’s principle. Consider the dissolution of silver iodide:
48.5K
Factors Affecting Dissolution: Drug pKa, Lipophilicity and GI pH01:21

Factors Affecting Dissolution: Drug pKa, Lipophilicity and GI pH

4.5K
Drug absorption within the gastrointestinal (GI) tract is a complex process influenced by several critical factors, including the site pH, the drug's dissociation constant (pKa), and the drug's lipophilicity. The GI tract exhibits a pH gradient, with an acidic environment in the stomach and a more alkaline environment in the small intestine. This pH variation directly affects the ionization state of drugs.
A drug's pKa and the pH of the gastrointestinal (GI) tract play crucial roles...
4.5K
Physical Properties Affecting Solubility02:19

Physical Properties Affecting Solubility

28.2K
Solutions of Gases in Liquids
As for any solution, the solubility of a gas in a liquid is affected by the attractive intermolecular forces between solute and solvent species. Unlike solid and liquid solutes, however, there is no solute-solute intermolecular attraction to overcome when a gaseous solute dissolves in a liquid solvent since the atoms or molecules comprising a gas are far separated and experience negligible interactions. Consequently, solute-solvent interactions are the sole...
28.2K
Intermolecular Forces in Solutions02:28

Intermolecular Forces in Solutions

41.2K
The formation of a solution is an example of a spontaneous process, a process that occurs under specified conditions without energy from some external source.
When the strengths of the intermolecular forces of attraction between solute and solvent species in a solution are no different than those present in the separated components, the solution is formed with no accompanying energy change. Such a solution is called an ideal solution. A mixture of ideal gases (or gases such as helium and argon,...
41.2K
Factors Affecting Solubility04:01

Factors Affecting Solubility

39.5K
Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Chȃtelier’s principle. Consider the dissolution of silver iodide:
39.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Mapping the Landscape of Open Access Dashboards - A Dataset for Research and Infrastructure Development.

Scientific data·2026
Same author

Nature of ammonia storage sites in H-SSZ-13 and Cu-SSZ-13.

RSC advances·2026
Same author

Mapping the Landscape of Open Access Dashboards - A Dataset for Research and Infrastructure Development.

Scientific data·2026
Same author

Strain-Induced Redistribution of Point Defects in ZnO Nanoparticles.

Small science·2026
Same author

Nickel Foam Electrodes-A Versatile, Powerful, and Readily Available Tool in Electro-Organic Synthesis.

Chemical record (New York, N.Y.)·2026
Same author

Platinum surface oxides govern the cathodic overpotential of the oxygen reduction reaction.

EES catalysis·2026
Same journal

Metal-Organic Framework Multizyme Colloids with Joint Antioxidant and Protease Function.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

Morphology Engineering of Co<sub>3</sub>O<sub>4</sub> via Cetyltrimethylammonium Bromide-Mediated ZIF-67 Synthesis for Efficient Photo-Assisted Electrooxidation of Methanol.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

Speciation of Silanol Groups on Commercial Precipitated Silicas via IR Spectroscopy.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

Regenerable PVA Hydrogel-Functionalized Optical Fiber Sensor for Ultra-Trace Detection of Berberine Hydrochloride.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

Hydrogen Plasma-Driven Surface Defect Engineering of ZnO Nanorods: Correlating Electronic Structure and Photoelectrochemical Performance.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

Cooperative Self-Assembly of Nanoparticle-Encapsulating Hybrid Protein Cages.

Langmuir : the ACS journal of surfaces and colloids·2026
See all related articles

Related Experiment Video

Updated: Apr 17, 2026

Analyzing Melts and Fluids from Ab Initio Molecular Dynamics Simulations with the UMD Package
06:37

Analyzing Melts and Fluids from Ab Initio Molecular Dynamics Simulations with the UMD Package

Published on: September 17, 2021

5.3K

Size effects in MgO cube dissolution.

Stefan O Baumann1, Johannes Schneider, Andreas Sternig

  • 1Institute of Particle Technology, Friedrich-Alexander Universität Erlangen-Nürnberg , Cauerstrasse 4, 91058 Erlangen, Germany.

Langmuir : the ACS Journal of Surfaces and Colloids
|February 11, 2015
PubMed
Summary
This summary is machine-generated.

Engineered magnesium oxide (MgO) nanomaterials dissolve and transform into magnesium hydroxide nanosheets in water. Smaller MgO nanocubes (<10 nm) dissolve rapidly, while larger microcrystalline MgO dissolves slowly due to surface inhibition effects.

More Related Videos

Dynamic Pore-scale Reservoir-condition Imaging of Reaction in Carbonates Using Synchrotron Fast Tomography
10:18

Dynamic Pore-scale Reservoir-condition Imaging of Reaction in Carbonates Using Synchrotron Fast Tomography

Published on: February 21, 2017

9.0K
A Technical Guide for Performing Spectroscopic Measurements on Metal-Organic Frameworks
10:13

A Technical Guide for Performing Spectroscopic Measurements on Metal-Organic Frameworks

Published on: April 28, 2023

3.3K

Related Experiment Videos

Last Updated: Apr 17, 2026

Analyzing Melts and Fluids from Ab Initio Molecular Dynamics Simulations with the UMD Package
06:37

Analyzing Melts and Fluids from Ab Initio Molecular Dynamics Simulations with the UMD Package

Published on: September 17, 2021

5.3K
Dynamic Pore-scale Reservoir-condition Imaging of Reaction in Carbonates Using Synchrotron Fast Tomography
10:18

Dynamic Pore-scale Reservoir-condition Imaging of Reaction in Carbonates Using Synchrotron Fast Tomography

Published on: February 21, 2017

9.0K
A Technical Guide for Performing Spectroscopic Measurements on Metal-Organic Frameworks
10:13

A Technical Guide for Performing Spectroscopic Measurements on Metal-Organic Frameworks

Published on: April 28, 2023

3.3K

Area of Science:

  • Materials Science
  • Environmental Science
  • Nanotechnology

Background:

  • Understanding the stability and dissolution of engineered nanomaterials (ENMs) in aqueous environments is crucial for assessing their environmental fate and functionality.
  • Magnesium oxide (MgO) nanoparticles are increasingly used, necessitating research into their behavior in water.

Purpose of the Study:

  • To investigate the stability and dissolution behavior of cubic MgO particles in aqueous systems.
  • To elucidate the transformation pathway of MgO into other magnesium compounds.
  • To compare the dissolution rates of MgO nanocubes and microcrystalline MgO.

Main Methods:

  • Scanning electron microscopy (SEM) for surface morphology.
  • Transmission electron microscopy (TEM) for nanoscale structural analysis.
  • X-ray diffraction (XRD) for crystallographic information.

Main Results:

  • MgO dissolution involves water dissociation, surface element disintegration, solvation, and Mg(OH)2 nanosheet precipitation.
  • MgO nanocubes (<10 nm) dissolve rapidly (minutes) at pH ≥ 10, forming Mg(OH)2 nanosheets.
  • Microcrystalline MgO (10 nm–1000 nm) exhibits slower dissolution due to surface hydroxide-induced self-inhibition effects on specific crystal faces.

Conclusions:

  • The morphology and surface faceting of ENMs significantly influence their dissolution behavior and transformation in aqueous media.
  • Engineered MgO nanomaterials undergo distinct dissolution pathways based on particle size and origin.
  • Environmental fate assessments must consider the dynamic evolution of ENM structure and properties.