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Factoring in Factor VIII With Acute Ischemic Stroke.

James E Siegler1, Alyana Samai2, Karen C Albright3

  • 1Department of Neurology, Tulane Stroke Research Program, Tulane Medical Center, New Orleans, LA, USA.

Clinical and Applied Thrombosis/Hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
|February 12, 2015
PubMed
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Elevated factor VIII levels are linked to cryptogenic stroke causes. Screening for factor VIII may aid in diagnosing and predicting outcomes for ischemic stroke patients.

Keywords:
factor viiihypercoagulabilitystrokethrombosisvon Willebrand factor

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Area of Science:

  • Neurology
  • Hematology
  • Cardiovascular Medicine

Background:

  • Cryptogenic stroke research is increasing, focusing on hypercoagulable states.
  • Elevated serum factor VIII levels are implicated in occult cerebral infarctions.

Purpose of the Study:

  • To review the molecular role of factor VIII in thrombogenesis.
  • To discuss the clinical utility of factor VIII in diagnosing and prognosing acute ischemic stroke.
  • To evaluate screening for serum factor VIII in at-risk or post-stroke patients.

Main Methods:

  • Literature review of factor VIII's role in stroke.
  • Analysis of diagnostic and prognostic applications of factor VIII.
  • Discussion of screening strategies for factor VIII levels.

Main Results:

  • Factor VIII is a key procoagulant in thrombogenesis.
  • Factor VIII levels correlate with ischemic stroke risk and outcomes.
  • Screening may identify patients benefiting from targeted therapies.

Conclusions:

  • Factor VIII is a significant factor in cryptogenic stroke.
  • Monitoring factor VIII levels can improve stroke diagnosis and prognosis.
  • Factor VIII screening is valuable for stroke risk assessment.