Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein Organization01:13

Protein Organization

161.9K
Overview
161.9K
Protein and Protein Structure02:15

Protein and Protein Structure

92.4K
Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme...
92.4K
Protein Organization01:13

Protein Organization

25.0K
No description available
25.0K
Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

15.0K
Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
15.0K
Protein Organization01:24

Protein Organization

10.0K
Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence....
10.0K
Protein Organization01:24

Protein Organization

10.0K
No description available
10.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Somatic deficiency of the human E3 ubiquitin ligase CBL in leukocytes impairs B cell but not T cell development and function.

Nature immunology·2026
Same author

Automating candidate gene prioritization with large language models: from naive scoring to literature-grounded validation.

Bioinformatics (Oxford, England)·2025
Same author

Human LY9 governs CD4<sup>+</sup> T cell IFN-γ immunity to <i>Mycobacterium tuberculosis</i>.

Science immunology·2025
Same author

From gene modules to gene markers: an integrated AI-human approach selects CD38 to represent plasma cell-associated transcriptional signatures.

Frontiers in medicine·2025
Same author

Tackling the Complexity of Spatial Transcriptomics Data Interpretation with Large Language Models.

bioRxiv : the preprint server for biology·2024
Same author

Impaired development of memory B cells and antibody responses in humans and mice deficient in PD-1 signaling.

Immunity·2024
Same journal

Anti-mycobacterial activity of phytocompounds from <i>Ricinus communis</i> L. - an integrated <i>in-vitro</i> and <i>in-silico</i> approach.

Journal of biomolecular structure & dynamics·2026
Same journal

Binding studies of the X-ray characterized [SnMe<sub>2</sub>Cl<sub>2</sub>(Me<sub>2</sub>phen)] complex with human serum albumin: experimental and molecular docking approaches.

Journal of biomolecular structure & dynamics·2026
Same journal

Computational design and experimental validation of peptide inhibitors to disrupt urease enzyme maturation in pathogenic bacteria <i>Proteus mirabilis</i>.

Journal of biomolecular structure & dynamics·2026
Same journal

Wavelet-domain multiway spectral separation of free drug, DNA, and drug-DNA complex profiles for quantitative binding analysis based on fractional occupancy (<i>θ</i>).

Journal of biomolecular structure & dynamics·2026
Same journal

Gene expression and microsecond scale conformational dynamics suggest potential regulatory mechanisms for the expanded subtilase family of <i>T. rubrum</i>.

Journal of biomolecular structure & dynamics·2026
Same journal

Deciphering the Role of Sugar Osmolytes in Free and Nano forms to Mitigate Protein Aggregation: Insights from Biophysical and Microscopic Studies.

Journal of biomolecular structure & dynamics·2026
See all related articles

Related Experiment Video

Updated: Apr 3, 2026

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
10:58

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

17.7K

Modularity in protein structures: study on all-alpha proteins.

Taushif Khan1, Indira Ghosh1

  • 1a School of Computational & Integrative Sciences , Jawaharlal Nehru University , New Delhi 110067 , India.

Journal of Biomolecular Structure & Dynamics
|February 12, 2015
PubMed
Summary
This summary is machine-generated.

Protein modularity, crucial for robust design, is explored using secondary structure patterns. Frequent patterns act as building blocks in larger proteins, suggesting function drives protein structure space.

Keywords:
Topology spacecontact stringenzyme reactionmodulesprevalent patternprotein functionsecondary structurestructural descriptor

More Related Videos

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

16.2K
Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids
08:21

Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids

Published on: April 13, 2022

3.2K

Related Experiment Videos

Last Updated: Apr 3, 2026

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
10:58

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

17.7K
Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

16.2K
Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids
08:21

Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids

Published on: April 13, 2022

3.2K

Area of Science:

  • Proteomics
  • Structural Biology
  • Biophysics

Background:

  • Protein modularity is key to robust and efficient biological design.
  • Protein architecture and topology provide essential scaffolds for survival under evolutionary pressure.
  • Understanding the smallest biologically relevant structural components is vital for deciphering protein complexity.

Purpose of the Study:

  • To develop a component-based method for investigating protein structural space using secondary structure patterns.
  • To explore the modular architecture of proteins and identify fundamental structural units.
  • To analyze the relationship between protein structure, patterns, and function.

Main Methods:

  • Developed a component-based method utilizing protein secondary structures and their arrangements.
  • Applied combinatorial and graph-based geometry methods to explore protein structural space.
  • Analyzed structural descriptors and functional occurrences of identified patterns in all-alpha proteins.

Main Results:

  • The structural space of all-alpha proteins is dominated by a limited set of frequently occurring structural patterns.
  • These frequent patterns serve as modular building blocks in larger proteins with higher secondary structure content.
  • Identified patterns exhibit similar deviations, but frequent patterns are distinctly associated with diverse enzymatic functions.

Conclusions:

  • A simple approach using combinatorial and graph-based geometry can effectively describe protein modularity.
  • Protein function appears to be the primary driving force shaping the observed protein structure space.
  • The study highlights the importance of modularity and identifies recurring structural patterns as fundamental units in protein design.