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Updated: Apr 17, 2026

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
Published on: October 27, 2020
14-3-3ζ turns TGF-β to the dark side
Peter ten Dijke1, Hans van Dam1
1Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands, Leiden University Medical Center, Postbus 9600, 2300 RC Leiden, the Netherlands; Ludwig Institute for Cancer Research, Science for Life Laboratory, Uppsala University, Box 595, 75124 Uppsala, Sweden.
Abstract:
TGF-β/SMAD signaling has long been known to exhibit a dual role in cancer, questioning what determines its context-dependent functions. In this issue of Cancer Cell, Xu and colleagues describe a critical role of the adaptor protein 14-3-3ζ in modulating SMAD activities by changing its interaction partners during breast cancer progression.
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