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Severity of stable coronary artery disease and its biomarkers differ between men and women undergoing angiography

Crystel M Gijsberts1, Aisha Gohar2, Guilielmus H J M Ellenbroek2

  • 1Laboratory of Experimental Cardiology, Division Heart and Lungs, University Medical Centre Utrecht, The Netherlands; ICIN-Netherlands Heart Institute, Utrecht, The Netherlands.

Atherosclerosis
|February 12, 2015
PubMed

Insights

Coronary artery disease (CAD) severity is lower in women than men. Biomarker associations with CAD severity did not differ between sexes in this coronary angiography study.

Area of Science:

  • Cardiology
  • Biomarkers
  • Sex Differences in Medicine

Background:

  • Coronary artery disease (CAD) affects both sexes, yet data on sex-specific cardiovascular biomarker associations with disease severity is limited.
  • Understanding these differences is crucial for tailored patient management and risk stratification.

Purpose of the Study:

  • To investigate the association of established cardiovascular biomarkers with coronary artery disease (CAD) severity in a sex-specific manner.
  • To analyze CAD severity using the SYNTAX score in stable patients undergoing coronary angiography.

Main Methods:

  • Studied stable patients undergoing coronary angiography, measuring CAD severity via SYNTAX score.
  • Assessed levels of N-terminal pro-brain natriuretic peptide (NT-proBNP), high-sensitivity C-reactive protein (hsCRP), cystatin C (CysC), myeloperoxidase (MPO), high-sensitivity troponin I (hsTnI), and von Willebrand factor (VWF).
  • Employed multivariable ANCOVA for sex differences and multivariable linear regression with interaction terms for sex to assess biomarker-SYNTAX score associations.

Main Results:

  • Analyzed data from 460 men and 175 women; women had significantly lower SYNTAX scores (9.99 vs. 11.88).
  • Univariate analysis showed hsCRP and hsTnI associated with SYNTAX scores.
  • Multivariable analysis revealed only hsCRP remained associated with SYNTAX score (β=1.9, p=0.009); sex did not modify this association.

Conclusions:

  • Coronary artery disease severity, assessed by SYNTAX score, is lower in women compared to men.
  • The relationship between cardiovascular biomarkers and CAD severity does not differ significantly between sexes.
Abstract

Keywords:
BiomarkersCoronary angiographyEpidemiologySex

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