Related Experiment Video
Updated: Apr 17, 2026
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
High-density lipoprotein subfractions in relation with the severity of coronary artery disease: A Gensini score
Rui-Xia Xu1, Sha Li1, Xiao-Lin Li1
1Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Insights
Smaller high-density lipoprotein (HDL) subfractions are linked to coronary artery disease (CAD) presence and severity. Larger HDL subfractions are associated with less severe CAD in patients not on statin therapy.
Area of Science:
- Cardiology
- Lipidology
- Biochemistry
Background:
- The precise role of high-density lipoprotein (HDL) subfractions in coronary artery disease (CAD) pathogenesis remains unclear.
- Understanding HDL subfractions' impact is crucial for CAD risk stratification.
Purpose of the Study:
- To investigate the association between different HDL subfractions and CAD severity.
- To analyze HDL subfractions in patients without statin therapy.
Main Methods:
- 382 patients undergoing coronary angiography were analyzed.
- Patients were categorized into CAD (n=283) and control (n=99) groups.
- HDL subfractions were quantified using Quantimetrix Lipoprint HDL; CAD severity was assessed by Gensini score.
Main Results:
- Patients with CAD had significantly lower levels and percentages of large HDL subfractions compared to controls.
- Conversely, patients with CAD showed significantly higher levels and percentages of small HDL subfractions.
- A higher percentage of large HDL subfractions correlated negatively with CAD severity (Gensini score), while small HDL subfractions correlated positively.
Conclusions:
- Small HDL subfractions are associated with the presence of CAD.
- The percentage of large HDL subfractions is negatively associated with CAD severity.
- The percentage of small HDL subfractions is positively associated with CAD severity.
Background:
The exact role of different high-density lipoprotein (HDL) subfractions in the pathogenesis of coronary artery disease (CAD) has not yet been fully explored. The aim of the present study was to examine the relationship between HDL subfractions and the severity of CAD in patients without statin therapy.
Methods:
A total of 382 consecutive patients (mean: 55.36 ± 11.30 years of age) who underwent coronary angiography from angina-like chest pain were investigated. Patients were classified into 2 groups according to the angiographic results: a CAD group (n = 283) and a control group (n = 99). The distribution of HDL subfractions was analyzed using a Quantimetrix Lipoprint HDL system. CAD severity was measured by Gensini score (GS).
Results:
Compared with the control group, HDL-cholesterol (HDL-C), large HDL-C level, and the large HDL subfraction percentages in the CAD group were significantly lower (P = .002, P < .001, P < .001, respectively). Meanwhile, a small HDL-C level and the percentage of small HDL subfraction were significantly higher (P = .003, P < .001, respectively). Correlation analysis showed that the percentage of a large HDL subfraction was negatively correlated with GS (β = -0.191, P = .005), whereas the percentage of a small HDL subfraction positively correlated with GS (β = 0.145, P = .023) in patients with CAD.
Conclusions:
Small HDL subfraction was associated with the presence of CAD, whereas the percentage of large HDL and small HDL subfraction was negatively and positively associated with the severity of CAD, respectively.
More Related Videos
09:15Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Published on: November 10, 2017
06:57Author Spotlight: Advancing Cardiovascular Imaging - Introducing the Spatially Weighted Calcium Score for Early Disease Detection
Published on: September 22, 2023
Related Concept Videos
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
01:26Coronary Artery Disease IV: Preventive Measures
01:30Coronary Artery Disease I: Introduction
01:26Coronary Artery Disease II: Pathophysiology
01:30Acute Coronary Syndrome III: Diagnostic Studies