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Updated: Apr 17, 2026

Rat Model of Blood-brain Barrier Disruption to Allow Targeted Neurovascular Therapeutics
Published on: November 30, 2012
Blood-brain barrier: an impediment to neuropharmaceuticals
J T Henderson1, M Piquette-Miller
1Leslie Dan Faculty of Pharmacy, University of Toronto, Ontario, Canada.
Abstract:
The blood-brain barrier (BBB) serves as a highly selective barrier separating the central nervous system from the systemic circulation. Although contributing to neurological health, the BBB restricts the ability of drugs to reach their site of action and thus presents a major challenge to the treatment of neurological disorders. Advances in our understanding of the complexity of the BBB have fostered development of novel pharmacometric models and drug delivery strategies to better predict and improve therapeutic access.
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