Related Experiment Video
Updated: Apr 17, 2026

An Open Source Technology Platform to Manufacture Hydrogel-Based 3D Culture Models in an Automated and Standardized Fashion
Published on: March 31, 2022
The impact of preclinical irreproducibility on drug development
1Global Biological Standards Institute, Washington, DC, USA.
Abstract:
The development of novel therapeutics depends and builds upon the validity and reproducibility of previously published data and findings. Yet irreproducibility is pervasive in preclinical life science research and can be traced to cumulative errors or flaws in several areas, including reference materials, study design, laboratory protocols, and data collection and analysis. The expanded development and use of consensus-based standards and well-documented best practices is needed to both enhance reproducibility and drive therapeutic innovations.
More Related Videos
Related Concept Videos
Preclinical Development: Overview
Drug Discovery: Overview
Clinical Trials: Overview
Clinically Relevant Drug Product Specifications: Methods of Establishment
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
In Vitro Drug Release Testing: Overview, Development and Validation

