Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Serotonin and alcohol: interrelationships.

G D Tollefson1

  • 1Department of Psychiatry, St. Paul-Ramsey Medical Center, Minn.

Psychopathology
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Treatment of schizophrenic disorders: Algorithms for acute pharmacotherapy.

International journal of psychiatry in clinical practice·2014
Same author

The double-blind variable placebo lead-in period: results from two antidepressant clinical trials.

Journal of clinical psychopharmacology·2002
Same author

Factors influencing acute weight change in patients with schizophrenia treated with olanzapine, haloperidol, or risperidone.

The Journal of clinical psychiatry·2001
Same author

Long-term olanzapine treatment: weight change and weight-related health factors in schizophrenia.

The Journal of clinical psychiatry·2001
Same author

Evidence for the effectiveness of olanzapine among patients nonresponsive and/or intolerant to risperidone.

The Journal of clinical psychiatry·2001
Same author

Double-blind comparison of olanzapine versus clozapine in schizophrenic patients clinically eligible for treatment with clozapine.

Biological psychiatry·2001

Alcoholism and anxiety are linked through serotonin (5-hydroxytryptamine, 5-HT). Enhancing 5-HT levels may reduce alcohol consumption and related behavioral issues, offering potential therapeutic targets.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • Alcoholism and anxiety disorders frequently co-occur, suggesting shared underlying mechanisms.
  • The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) plays a crucial role in regulating mood and behavior, and is implicated in both alcoholism and anxiety.

Purpose of the Study:

  • To explore the intricate relationship between serotonin pathways and the development and manifestation of alcoholism and anxiety.
  • To investigate the potential of targeting serotonin systems for therapeutic interventions in these conditions.

Main Methods:

  • Review of existing literature on serotonin's role in alcohol consumption and anxiety.
  • Analysis of studies examining 5-HT turnover, platelet 5-HT content, and cerebrospinal fluid (CSF) 5-hydroxyindoleacetic acid in relation to alcohol use.

Related Experiment Videos

  • Examination of preliminary research on 5-HT-enhancing agents and their effects on alcohol consumption and related behaviors.

    • Main Results:

    • Serotonin activation appears to reduce alcohol intake, while depletion exacerbates it.
    • Chronic alcohol use is associated with altered serotonin turnover and reduced platelet 5-HT uptake, potentially contributing to anxiety and depression.
    • Alcohol consumption can lead to the formation of psychotropic aldehydes, such as beta-carbolines.
    • Preliminary studies indicate that 5-HT-enhancing drugs decrease alcohol consumption and memory impairments.

    Conclusions:

    • Serotonin (5-HT) is a key neurochemical link between alcoholism and anxiety disorders.
    • Modulating serotonin pathways, particularly through 5-HT-enhancing agents, shows promise in reducing alcohol consumption and associated cognitive deficits.