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Related Concept Videos

Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Mitochondria01:37

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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Drug Dosing: Geriatric Patients01:15

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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

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As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
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Antiaging therapy: a prospective hypothesis.

Mohammad Rashid Shahidi Bonjar1, Leyla Shahidi Bonjar2

  • 1School of Dentistry, Kerman University of Medical Sciences, Kerman Iran.

Drug Design, Development and Therapy
|February 12, 2015
PubMed
Summary
This summary is machine-generated.

This hypothesis proposes an anti-aging blood filtration column (AABFC) to reduce aging-related molecules (ARMs) in the blood, potentially slowing aging and age-related diseases in humans.

Keywords:
NF-κBagingblood filtrationlifespannanotechnologyrejuvenation

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Area of Science:

  • Gerontology and Regenerative Medicine
  • Nanotechnology and Biomedical Engineering
  • Molecular Biology and Immunology

Background:

  • Systemic aging is influenced by specific molecules circulating in the blood.
  • Elevated levels of aging-related molecules (ARMs) have been identified as triggers for the aging cascade.
  • Previous research demonstrated that inhibiting ARMs can reduce age-related cognitive and physical decline in mice.

Purpose of the Study:

  • To propose a novel prospective approach for slowing the human aging process.
  • To translate findings on ARMs into a potential medical treatment for age-related illnesses.
  • To introduce the concept of an anti-aging blood filtration column (AABFC) for extracorporeal adjustment of ARMs.

Main Methods:

  • The proposed method involves an anti-aging blood filtration column (AABFC), a nanotechnological device.
  • The AABFC would immobilize ARMs from circulating blood using antibodies conjugated to its internal surfaces.
  • Blood circulation would mimic renal dialysis, passing from the body to the AABFC and back until a near-youth homeostatic titer of ARMs is achieved.

Main Results:

  • The hypothesis suggests that extracorporeal adjustment of ARMs can lead to slower rates of aging.
  • The AABFC aims to restore ARMs to a near-youth homeostatic level, mitigating aging processes.
  • Successful implementation could reduce age-related cognitive and physical declines.

Conclusions:

  • The AABFC technology offers a potential pathway to significantly slow aging and extend healthy human lifespans.
  • This approach could lead to novel treatments for various age-related diseases, including Alzheimer's and arthritis.
  • Further investigations are required to determine optimal application criteria and validate the technology's efficacy and safety in humans.