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Association of hair manganese level with symptoms in attention-deficit/hyperactivity disorder

Dong-Won Shin1, Eun-Ji Kim2, Se-Won Lim1

  • 1Department of Psychiatry, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Psychiatry Investigation
|February 12, 2015
PubMed

Insights

Hair manganese levels, both high and low, are linked to attention-deficit/hyperactivity disorder (ADHD) in Korean children. This suggests manganese may play a role in ADHD development.

Area of Science:

  • Pediatric Neurodevelopment
  • Environmental Toxicology
  • Child Psychiatry

Background:

  • Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in children.
  • Manganese (Mn) is an essential trace element, but its neurotoxicity is also recognized.
  • Hair mineral analysis is a non-invasive method to assess long-term exposure to elements like manganese.

Purpose of the Study:

  • To investigate the association between hair manganese levels and ADHD in Korean children.
  • To determine if either manganese deficiency or excess is related to ADHD symptoms.

Main Methods:

  • Study included 40 children diagnosed with ADHD and 43 healthy controls (ages 6-15) from Seoul, Korea.
  • ADHD diagnosis and symptom severity were assessed using standardized criteria and rating scales.
  • Hair manganese levels were analyzed and categorized to compare ADHD patients with controls, controlling for age, sex, and IQ.

Main Results:

  • A higher proportion of children with ADHD exhibited abnormal hair manganese levels compared to controls.
  • Abnormal manganese levels remained significantly associated with ADHD after adjusting for covariates (OR=6.40, p=0.017).

Conclusions:

  • Both excess exposure and deficiency of manganese are associated with ADHD in Korean children.
  • Further research is warranted to elucidate the specific role of hair manganese levels in ADHD symptomatology.
Abstract

Keywords:
Attention-deficit/hyperactivity disorderHairManganese

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