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Efficient deprotection of F-BODIPY derivatives: removal of BF2 using Brønsted acids
Mingfeng Yu1, Joseph K-H Wong1, Cyril Tang1
1School of Chemistry, The University of Sydney, Sydney, New South Wales 2006, Australia.
Abstract:
The effective and efficient removal of the BF2 moiety from F-BODIPY derivatives has been achieved using two common Brønsted acids; treatment with trifluoroacetic acid (TFA) or methanolic hydrogen chloride (HCl) followed by work-up with Ambersep(®) 900 resin (hydroxide form) effects this conversion in near-quantitative yields. Compared to existing methods, these conditions are relatively mild and operationally simple, requiring only reaction at room temperature for six hours (TFA) or overnight (HCl).
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