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Nanoscaled aptasensors for multi-analyte sensing.
Mehdi Saberian-Borujeni1, Mohammad Johari-Ahar1, Hossein Hamzeiy1
1Research Center for Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Bioimpacts : BI
|February 12, 2015
Summary
Aptasensors, which are nanoscale aptamers, offer powerful diagnostic tools for detecting various molecules in biological samples. Future challenges include developing aptasensors for simultaneous detection in complex biological matrices.
Area of Science:
- Biotechnology
- Nanotechnology
- Analytical Chemistry
Background:
- Nanoscaled aptamers (Aps) are short DNA/RNA oligonucleotides with high target-binding affinity.
- Aptamers are selected via systematic evolution of ligands by exponential enrichment (SELEX).
- Aptasensors are diagnostic and analytical tools utilizing aptamers for target detection.
Purpose of the Study:
- Review and discuss recent advancements in aptasensor technology.
- Focus on the potential of aptasensors for multianalyte detection.
Main Methods:
- Literature review of recent studies on aptasensors.
- Discussion focused on multianalyte detection capabilities.
Main Results:
- Aptasensors successfully detect diverse small and large molecules (drugs, toxins, biomarkers) at low concentrations.
- Detection is effective in biological fluids despite interfering species.
- Specific aptamer folding upon analyte binding enables sensitive detection.
Conclusions:
- Detecting multiple targets simultaneously in complex biological samples is a key challenge.
- Integration of bioengineering, systems biology, and biomedical research is crucial for advancing aptasensor technology.
- Development of robust aptasensors for real-world biological matrices is essential.
