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Bolaamphiphiles: a pharmaceutical review
Mayur Fariya1, Ankitkumar Jain1, Vivek Dhawan1
1Department of Pharmaceutics, Bombay College of Pharmacy, Kalina, Santacruz (E), Mumbai - 400098, India.
Advanced Pharmaceutical Bulletin
|February 12, 2015
Summary
Bolaamphiphiles, a novel class of molecules, are explored for their self-assembly properties. These compounds show significant promise for developing advanced nanocarriers in drug discovery and delivery.
Area of Science:
- Medicinal Chemistry
- Materials Science
- Nanotechnology
Background:
- Excipients are crucial in the expanding field of drug discovery.
- Bolaamphiphiles represent a unique class of amphiphilic molecules with diverse applications.
- Their self-assembly behavior is key to their utility in pharmaceutical formulations.
Purpose of the Study:
- To review natural and synthetic bolaamphiphiles.
- To highlight their chemical structures and self-assembly capabilities.
- To explore their potential in drug and gene delivery systems.
Main Methods:
- Literature review of bolaamphiphile research.
- Analysis of chemical structures and self-assembly mechanisms.
- Examination of recent applications in nanocarrier fabrication.
Main Results:
- Bolaamphiphiles, both natural and synthetic, exhibit remarkable self-assembly properties.
- These properties enable their use in creating effective nanosized drug and gene carriers.
- Recent studies demonstrate their substantial potential for targeted delivery.
Conclusions:
- Bolaamphiphiles are highly valuable excipients in modern drug discovery.
- Their self-assembly characteristics are pivotal for advanced drug delivery systems.
- Further research into bolaamphiphiles will likely yield innovative therapeutic solutions.
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